Tumor-derived osteopontin isoforms cooperate with TRP53 and CCL2 to promote lung metastasis

The lungs are ubiquitous receptacles of metastases originating from various bodily tumors. Although osteopontin (SPP1) has been associated with tumor dissemination, the role of its isoforms in lung-directed metastasis is incompletely understood. We employed syngeneic mouse models of spontaneous and...

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Autors principals: Giopanou, I, Lilis, I, Papaleonidopoulos, V, Agalioti, T, Kanellakis, NI, Spiropoulou, N, Spella, M, Stathopoulos, GT
Format: Journal article
Publicat: Taylor and Francis 2016