Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.

Activation of cellular transcriptional responses, mediated by hypoxia-inducible factor (HIF), is common in many types of cancer, and generally confers a poor prognosis. Known to induce many hundreds of protein-coding genes, HIF has also recently been shown to be a key regulator of the non-coding tra...

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Autors principals:	Choudhry, H, Albukhari, A, Morotti, M, Hider, S, Moralli, D, Smythies, J, Schödel, J, Green, C, Camps, C, Buffa, F, Ratcliffe, P, Ragoussis, J, Harris, A, Mole, DR
Format:	Journal article
Idioma:	English
Publicat:	Nature Publishing Group 2014

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