The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein

The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein

The hepatitis C virus (HCV) encodes the p7 protein that oligomerizes to form an ion channel. The 63 amino acid long p7 monomer is an integral membrane protein predominantly found in the endoplasmic reticulum (ER). Although it is currently unknown whether p7 is incorporated into secreted virions, its...

Podrobná bibliografie
Hlavní autoři:	Whitfield, T, Miles, A, Scheinost, J, Offer, J, Wentworth, P, Dwek, R, Wallace, B, Biggin, P, Zitzmann, N
Médium:	Journal article
Jazyk:	English
Vydáno:	Taylor and Francis 2011

Podobné jednotky

The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy.
Autor: Luik, P, a další
Vydáno: (2009)

Protein-protein interactions: modeling the hepatitis C virus ion channel p7.
Autor: Patargias, G, a další
Vydáno: (2005)

The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives.
Autor: Pavlović, D, a další
Vydáno: (2003)

Deciphering the Relationship Between Hepatitis C Virus (HCV) P7 and Its Foes
Autor: Chew, C, a další
Vydáno: (2010)

Use of iminosugar derivatives to inhibit ion channel activity
Autor: Zitzmann, N, a další
Vydáno: (2004)

Determination of pore-lining residues in the hepatitis C virus p7 protein.
Autor: Chew, C, a další
Vydáno: (2009)

Long alkylchain iminosugars block the HCV p7 ion channel
Autor: Pavlovic, D, a další
Vydáno: (2005)

Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus.
Autor: Steinmann, E, a další
Vydáno: (2007)

The Hepatitis C Virus E2p7 localization and topology in a recombinant system
Autor: Popescu, C, a další
Vydáno: (2009)

Simulation approaches to ion channel gating
Autor: Biggin, P, a další
Vydáno: (2002)

State-dependent protein-lipid interactions of a pentameric ligand-gated ion channel in a neuronal membrane
Autor: Dämgen, MA, a další
Vydáno: (2021)

Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment
Autor: Bharambe, Nikhil, a další
Vydáno: (2024)

Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment
Autor: Nikhil Bharambe, a další
Vydáno: (2024-04-01)

Exploiting the defensive sugars of HIV-1 for drug and vaccine design
Autor: Scanlan, C, a další
Vydáno: (2007)

Structure of the Human BK Ion Channel in Lipid Environment
Autor: Lige Tonggu, a další
Vydáno: (2022-07-01)

State-dependent protein-lipid interactions of a pentameric ligand-gated ion channel in a neuronal membrane.
Autor: Marc A Dämgen, a další
Vydáno: (2021-02-01)

Simulation approaches to ion channel structure-function relationships.
Autor: Tieleman, D, a další
Vydáno: (2001)

Use of castanospermine and substituted-castonospermine compounds for treating hepatitis virus infections
Autor: Jacob, G, a další
Vydáno: (2001)

Ion channel gating: insights via molecular simulations.
Autor: Beckstein, O, a další
Vydáno: (2003)

Water in ion channels and pores--simulation studies.
Autor: Sansom, MS, a další
Vydáno: (2002)

Clinical diagnosis of hepatic fibrosis using human serum APOL1 as biomarker
Autor: Gangadharan, B, a další
Vydáno: (2012)

The p7 protein of hepatitis C virus forms structurally plastic, minimalist ion channels.
Autor: Danielle E Chandler, a další
Vydáno: (2012-01-01)

Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope.
Autor: Cygan, N, a další
Vydáno: (2011)

Clinical diagnosis of hepatic fibrosis using a novel panel of human serum protein biomarkers
Autor: Gangadharan, B, a další
Vydáno: (2008)

Differential effect of p7 inhibitors on hepatitis C virus cell-to-cell transmission.
Autor: Meredith, L, a další
Vydáno: (2013)

Clinical diagnosis of hepatic fibrosis using a novel panel of low abundant human plasma protein biomarkers
Autor: Gangadharan, B, a další
Vydáno: (2010)

Voltage-Gated Lipid Ion Channels.
Autor: Andreas Blicher, a další
Vydáno: (2013-01-01)

Novel serum biomarker candidates for liver fibrosis in hepatitis C patients
Autor: Gangadharan, B, a další
Vydáno: (2007)

Potassium and sodium ions in a potassium channel studied by molecular dynamics simulations.
Autor: Biggin, P, a další
Vydáno: (2001)

Sugar immunogens
Autor: Dwek, R, a další
Vydáno: (2009)

Ion-channel function and cross-species determinants in viral assembly of nonprimate hepacivirus p7
Autor: Walter, S, a další
Vydáno: (2016)

K(+) versus Na(+) ions in a K channel selectivity filter: a simulation study.
Autor: Shrivastava, I, a další
Vydáno: (2002)

Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: Implications for the development of broad spectrum anti-hepatitis virus agents
Autor: Zitzmann, N, a další
Vydáno: (1999)

SIRT7 and hepatic lipid metabolism
Autor: Bor Luen eTang
Vydáno: (2015-01-01)

The N-terminal Helical Region of the Hepatitis C Virus p7 Ion Channel Protein Is Critical for Infectious Virus Production.
Autor: Margaret A Scull, a další
Vydáno: (2015-11-01)

Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling.
Autor: Simmons, A, a další
Vydáno: (2005)

Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells.
Autor: Pollock, S, a další
Vydáno: (2010)

Recent Insight into Lipid Binding and Lipid Modulation of Pentameric Ligand-Gated Ion Channels
Autor: Anna Ananchenko, a další
Vydáno: (2022-06-01)

Inhibitor Development against p7 Channel in Hepatitis C Virus
Autor: Shukun Wei, a další
Vydáno: (2021-03-01)

Modulation of a rapid neurotransmitter receptor-ion channel by membrane lipids
Autor: Francisco J. Barrantes
Vydáno: (2024-01-01)