PRC1 catalytic activity is central to Polycomb system function

The Polycomb repressive system is an essential chromatin-based regulator of gene expression. Despite being extensively studied, how the Polycomb system selects its target genes is poorly understood, and whether its histone-modifying activities are required for transcriptional repression remains cont...

Full description

Bibliographic Details
Main Authors: Blackledge, NP, Fursova, NA, Kelley, JR, Huseyin, MK, Feldmann, A, Klose, RJ
Format: Journal article
Language:English
Published: Elsevier 2019