Endothelial dysfunction: potential clinical implications.
Vascular endothelium is responsible for the secretion of several substances exerting anti-atherogenic effects. Endothelial damage is also crucial for the progress of atherosclerosis and risk factors for atherosclerosis represent crucial factors associated with endothelial dysfunction. Studies have s...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1826304275051970560 |
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| author | Tousoulis, D Koutsogiannis, M Papageorgiou, N Siasos, G Antoniades, C Tsiamis, E Stefanadis, C |
| author_facet | Tousoulis, D Koutsogiannis, M Papageorgiou, N Siasos, G Antoniades, C Tsiamis, E Stefanadis, C |
| author_sort | Tousoulis, D |
| collection | OXFORD |
| description | Vascular endothelium is responsible for the secretion of several substances exerting anti-atherogenic effects. Endothelial damage is also crucial for the progress of atherosclerosis and risk factors for atherosclerosis represent crucial factors associated with endothelial dysfunction. Studies have shown that patients with cardiovascular disease are characterized by impaired endothelial function (EF). Therefore, several agents have been proposed as potential modulators of EF. Most of the available approaches include pharmaceutical agents routinely used such as statins, angiotensin converting enzyme inhibitors, antioxidants, L-arginine, insulin sensitizers or others still under investigation such as tetrahydrobiopterin or folic acid (folate). Despite of the fact that there are several strategies aiming to improve endothelial dysfunction by enhancing nitric oxide bioavailability, it is still unclear whether they could be beneficial at a clinical level. |
| first_indexed | 2024-03-07T06:15:19Z |
| format | Journal article |
| id | oxford-uuid:f0e539ec-74e7-40d8-8d56-57da70e20a50 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:15:19Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:f0e539ec-74e7-40d8-8d56-57da70e20a502022-03-27T11:51:34ZEndothelial dysfunction: potential clinical implications.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f0e539ec-74e7-40d8-8d56-57da70e20a50EnglishSymplectic Elements at Oxford2010Tousoulis, DKoutsogiannis, MPapageorgiou, NSiasos, GAntoniades, CTsiamis, EStefanadis, CVascular endothelium is responsible for the secretion of several substances exerting anti-atherogenic effects. Endothelial damage is also crucial for the progress of atherosclerosis and risk factors for atherosclerosis represent crucial factors associated with endothelial dysfunction. Studies have shown that patients with cardiovascular disease are characterized by impaired endothelial function (EF). Therefore, several agents have been proposed as potential modulators of EF. Most of the available approaches include pharmaceutical agents routinely used such as statins, angiotensin converting enzyme inhibitors, antioxidants, L-arginine, insulin sensitizers or others still under investigation such as tetrahydrobiopterin or folic acid (folate). Despite of the fact that there are several strategies aiming to improve endothelial dysfunction by enhancing nitric oxide bioavailability, it is still unclear whether they could be beneficial at a clinical level. |
| spellingShingle | Tousoulis, D Koutsogiannis, M Papageorgiou, N Siasos, G Antoniades, C Tsiamis, E Stefanadis, C Endothelial dysfunction: potential clinical implications. |
| title | Endothelial dysfunction: potential clinical implications. |
| title_full | Endothelial dysfunction: potential clinical implications. |
| title_fullStr | Endothelial dysfunction: potential clinical implications. |
| title_full_unstemmed | Endothelial dysfunction: potential clinical implications. |
| title_short | Endothelial dysfunction: potential clinical implications. |
| title_sort | endothelial dysfunction potential clinical implications |
| work_keys_str_mv | AT tousoulisd endothelialdysfunctionpotentialclinicalimplications AT koutsogiannism endothelialdysfunctionpotentialclinicalimplications AT papageorgioun endothelialdysfunctionpotentialclinicalimplications AT siasosg endothelialdysfunctionpotentialclinicalimplications AT antoniadesc endothelialdysfunctionpotentialclinicalimplications AT tsiamise endothelialdysfunctionpotentialclinicalimplications AT stefanadisc endothelialdysfunctionpotentialclinicalimplications |