Artemisinin derivatives in the treatment of falciparum malaria in pregnancy.

An artemisinin derivative (artesunate or artemether) was used for the treatment of multidrug-resistant Plasmodium falciparum malaria in 83 Karen pregnant women in Thailand; 55 women were treated for recrudescent infection following quinine or mefloquine, 12 for uncomplicated hyperparasitaemic episod...

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Bibliografische gegevens
Hoofdauteurs: Mcgready, R, Cho, T, Cho, J, Simpson, J, Luxemburger, C, Dubowitz, L, Looareesuwan, S, White, N, Nosten, F
Formaat: Journal article
Taal:English
Gepubliceerd in: 1998
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author Mcgready, R
Cho, T
Cho, J
Simpson, J
Luxemburger, C
Dubowitz, L
Looareesuwan, S
White, N
Nosten, F
author_facet Mcgready, R
Cho, T
Cho, J
Simpson, J
Luxemburger, C
Dubowitz, L
Looareesuwan, S
White, N
Nosten, F
author_sort Mcgready, R
collection OXFORD
description An artemisinin derivative (artesunate or artemether) was used for the treatment of multidrug-resistant Plasmodium falciparum malaria in 83 Karen pregnant women in Thailand; 55 women were treated for recrudescent infection following quinine or mefloquine, 12 for uncomplicated hyperparasitaemic episodes, and 16 had not declared their pregnancy when treated. The women were followed weekly until delivery. Artesunate and artemether were well tolerated and there was no drug-related adverse effect. Recrudescence within 42 d occurred in 16% of the treated episodes. Overall 73 pregnancies (88%) resulted in live births, 3 (4%) in abortions and 2 (3%) in still births, and 5 women were lost to follow-up before delivery. There was no congenital abnormality in any of the newborn children, and the 46 children followed for more than one year all developed normally.
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spelling oxford-uuid:f0efd08e-59dc-42b0-945f-dc5b0d79ed1f2022-03-27T11:51:59ZArtemisinin derivatives in the treatment of falciparum malaria in pregnancy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f0efd08e-59dc-42b0-945f-dc5b0d79ed1fEnglishSymplectic Elements at Oxford1998Mcgready, RCho, TCho, JSimpson, JLuxemburger, CDubowitz, LLooareesuwan, SWhite, NNosten, FAn artemisinin derivative (artesunate or artemether) was used for the treatment of multidrug-resistant Plasmodium falciparum malaria in 83 Karen pregnant women in Thailand; 55 women were treated for recrudescent infection following quinine or mefloquine, 12 for uncomplicated hyperparasitaemic episodes, and 16 had not declared their pregnancy when treated. The women were followed weekly until delivery. Artesunate and artemether were well tolerated and there was no drug-related adverse effect. Recrudescence within 42 d occurred in 16% of the treated episodes. Overall 73 pregnancies (88%) resulted in live births, 3 (4%) in abortions and 2 (3%) in still births, and 5 women were lost to follow-up before delivery. There was no congenital abnormality in any of the newborn children, and the 46 children followed for more than one year all developed normally.
spellingShingle Mcgready, R
Cho, T
Cho, J
Simpson, J
Luxemburger, C
Dubowitz, L
Looareesuwan, S
White, N
Nosten, F
Artemisinin derivatives in the treatment of falciparum malaria in pregnancy.
title Artemisinin derivatives in the treatment of falciparum malaria in pregnancy.
title_full Artemisinin derivatives in the treatment of falciparum malaria in pregnancy.
title_fullStr Artemisinin derivatives in the treatment of falciparum malaria in pregnancy.
title_full_unstemmed Artemisinin derivatives in the treatment of falciparum malaria in pregnancy.
title_short Artemisinin derivatives in the treatment of falciparum malaria in pregnancy.
title_sort artemisinin derivatives in the treatment of falciparum malaria in pregnancy
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