Short Vi-polysaccharide abrogates T-independent immune response and hyporesponsiveness elicited by long Vi-CRM197 conjugate vaccine

Short Vi-polysaccharide abrogates T-independent immune response and hyporesponsiveness elicited by long Vi-CRM197 conjugate vaccine

Polysaccharide-protein conjugates have been developed to overcome the T-independent response, hyporesponsiveness to repeated vaccination, and poor immunogenicity in infants of polysaccharides. To address the impact of polysaccharide length, typhoid conjugates made with short- and long-chain fraction...

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Bibliografiske detaljer
Main Authors:	Micoli, F, Bjarnarson, SP, Arcuri, M, Aradottir Pind, AA, Magnusdottir, GJ, Necchi, F, Di Benedetto, R, Carducci, M, Schiavo, F, Giannelli, C, Pisoni, I, Martin, LB, Del Giudice, G, MacLennan, CA, Rappuoli, R, Jonsdottir, I, Saul, A
Format:	Journal article
Sprog:	English
Udgivet:	National Academy of Sciences 2020

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