Development of SYK NanoBRET cellular target engagement assays for gain–of–function variants

Development of SYK NanoBRET cellular target engagement assays for gain–of–function variants

Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase that is activated by phosphorylation events downstream of FcR, B-cell and T-cell receptors, integrins, and C-type lectin receptors. When the tandem Src homology 2 (SH2) domains of SYK bind to phosphorylated immunoreceptor tyrosine-based...

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Bibliographic Details
Main Authors:	Capener, JL, Vasta, JD, Katis, VL, Michaud, A, Beck, MT, Daglish, SCD, Cohen-Kedar, S, Shaham Barda, E, Howell, S, Dotan, I, Robers, MB, Axtman, AD, Bashore, FM
Format:	Journal article
Language:	English
Published:	Frontiers Media 2024

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