Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

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The citric acid cycle (CAC) metabolite fumarate has been proposed to be cardioprotective; however, its mechanisms of action remain to be determined. To augment cardiac fumarate levels and to assess fumarate's cardioprotective properties, we generated fumarate hydratase (Fh1) cardiac knockout (K...

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Bibliographic Details
Main Authors: Ashrafian, H, Czibik, G, Bellahcene, M, Aksentijević, D, Smith, A, Mitchell, S, Dodd, M, Kirwan, J, Byrne, J, Ludwig, C, Isackson, H, Yavari, A, Støttrup, N, Contractor, H, Cahill, T, Sahgal, N, Ball, DR, Birkler, R, Hargreaves, I, Tennant, D, Land, J, Lygate, C, Johannsen, M, Kharbanda, R, Neubauer, S
Format: Journal article
Language:English
Published: 2012

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