A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands.

A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands.

Drosophila has three membrane-tethered epidermal growth factor (EGF)-like proteins: Spitz, Gurken and Keren. Spitz and Gurken have been genetically confirmed to activate the EGF receptor, but Keren is uncharacterized. Spitz is activated by regulated intracellular translocation and cleavage by the tr...

Podrobná bibliografie
Hlavní autoři:	Urban, S, Lee, JR, Freeman, M
Médium:	Journal article
Jazyk:	English
Vydáno:	2002

Podobné jednotky

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases.
Autor: Urban, S, a další
Vydáno: (2001)

An Arabidopsis Rhomboid homolog is an intramembrane protease in plants.
Autor: Kanaoka, M, a další
Vydáno: (2005)

Mechanism and function of the intramembrane-cleaving protease rhomboid
Autor: Lemberg, M, a další
Vydáno: (2005)

Mechanism and function of the intramembrane-cleaving protease rhomboid
Autor: Lemberg, M, a další
Vydáno: (2005)

Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases.
Autor: Lemberg, M, a další
Vydáno: (2005)

Rhomboids and intramembrane proteolysis
Autor: Freeman, M, a další
Vydáno: (2005)

A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling.
Autor: Wasserman, J, a další
Vydáno: (2000)

Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain.
Autor: Urban, S, a další
Vydáno: (2003)

Rhomboid intramembrane proteases: from substrate specificity and mechanism to biological function
Autor: Strisovsky, K, a další
Vydáno: (2009)

Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases.
Autor: Lemberg, M, a další
Vydáno: (2007)

Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases.
Autor: Pierrat, O, a další
Vydáno: (2011)

Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic rhomboids.
Autor: Urban, S, a další
Vydáno: (2002)

Mammalian EGF receptor activation by the rhomboid protease RHBDL2.
Autor: Adrain, C, a další
Vydáno: (2011)

Intramembrane proteolysis by rhomboids: catalytic mechanisms and regulatory principles.
Autor: Vinothkumar, K, a další
Vydáno: (2013)

Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα
Autor: Wunderle, L, a další
Vydáno: (2016)

Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates.
Autor: Strisovsky, K, a další
Vydáno: (2009)

Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila.
Autor: Lee, JR, a další
Vydáno: (2001)

Rhomboids: 7 years of a new protease family.
Autor: Freeman, M
Vydáno: (2009)

Lipid-polymer nanoparticles to probe the native-like environment of intramembrane rhomboid protease GlpG and its activity
Autor: Henry Sawczyc, a další
Vydáno: (2024-08-01)

Rhomboid proteases and their biological functions.
Autor: Freeman, M
Vydáno: (2008)

Mitochondrial membrane remodelling regulated by a conserved rhomboid protease.
Autor: McQuibban, G, a další
Vydáno: (2003)

Rhomboid proteases and growth factor signaling
Autor: Freeman, M
Vydáno: (2009)

GlyGly-CTERM and rhombosortase: a C-terminal protein processing signal in a many-to-one pairing with a rhomboid family intramembrane serine protease.
Autor: Daniel H Haft, a další
Vydáno: (2011-01-01)

Substrates and physiological functions of secretase rhomboids proteases
Autor: Freeman, M, a další
Vydáno: (2016)

Bacterial rhomboid proteases mediate quality control of orphan membrane proteins
Autor: Liu, G, a další
Vydáno: (2020)

Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics
Autor: Syed M Moin, a další
Vydáno: (2012-11-01)

Signaling Functions of Intramembrane Aspartyl-Proteases
Autor: Alkmini A. Papadopoulou, a další
Vydáno: (2020-12-01)

Rhomboid proteases in human disease: mechanisms and future prospects
Autor: Düsterhöft, S, a další
Vydáno: (2017)

Diverse substrate recognition mechanisms for rhomboids; thrombomodulin is cleaved by Mammalian rhomboids.
Autor: Lohi, O, a další
Vydáno: (2004)

Proteolysis within the membrane: rhomboids revealed.
Autor: Freeman, M
Vydáno: (2004)

Intramembrane-cleaving proteases (I-CLiPs) /
Autor: Hooper, Nigel M., a další
Vydáno: (2007)

Identification of an archaeal presenilin-like intramembrane protease.
Autor: Celia Torres-Arancivia, a další
Vydáno: (2010-01-01)

A Subset of Membrane-Altering Agents and γ-Secretase Modulators Provoke Nonsubstrate Cleavage by Rhomboid Proteases
Autor: Siniša Urban, a další
Vydáno: (2014-09-01)

Rhomboids.
Autor: Freeman, M
Vydáno: (2003)

The structural basis for catalysis and substrate specificity of a rhomboid protease.
Autor: Vinothkumar, K, a další
Vydáno: (2010)

Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function.
Autor: McQuibban, G, a další
Vydáno: (2006)

Intramembrane proteolysis controls diverse signalling pathways throughout evolution.
Autor: Urban, S, a další
Vydáno: (2002)

Expression and characterization of Drosophila signal peptide peptidase-like (sppL), a gene that encodes an intramembrane protease.
Autor: David J Casso, a další
Vydáno: (2012-01-01)

Intramembrane protease RasP boosts protein production in Bacillus
Autor: Jolanda Neef, a další
Vydáno: (2017-04-01)

Structure of rhomboid protease in complex with β-lactam inhibitors defines the S2' cavity.
Autor: Vinothkumar, K, a další
Vydáno: (2013)