Inhibition of Bruton's tyrosine kinase regulates macrophage NF-κB and NLRP3 inflammasome activation in metabolic inflammation

Inhibition of Bruton's tyrosine kinase regulates macrophage NF-κB and NLRP3 inflammasome activation in metabolic inflammation

Background and Purpose Currently there are limited medicines available for the treatment of metabolic inflammation in diseases such as obesity and type 2 diabetes (T2D). Although initially associated with B‐ells, Bruton's tyrosine kinase (BTK) is present in a wide variety of cells including mon...

Полное описание

Библиографические подробности
Главные авторы:	Purvis, GSD, Collino, M, Aranda-Tavio, H, Chiazza, F, O'Riordan, CE, Zeboudj, L, Mohammad, S, Collotta, D, Verta, R, Guisot, NES, Bunyard, P, Yaqoob, MM, Greaves, DR, Thiemermann, C
Формат:	Journal article
Язык:	English
Опубликовано:	Wiley 2020

Схожие документы

Bruton's tyrosine kinase inhibition attenuates the cardiac dysfunction caused by cecal ligation and puncture in mice
по: O'Riordan, CE, и др.
Опубликовано: (2019)

Bruton's TK regulates myeloid cell recruitment during acute inflammation
по: Purvis, GSD, и др.
Опубликовано: (2022)

X-linked immunodeficient mice with no functional Bruton's tyrosine kinase are protected from sepsis-induced multiple organ failure
по: O'Riordan, CE, и др.
Опубликовано: (2020)

Brutinib has anti‐inflammatory and anti‐diabetic effects in a model of HFD‐ induced insulin resistance and diabetic nephropathy
по: Purvis, GS, и др.
Опубликовано: (2019)

Quantitative proteomics to unravel NLRP3 inflammasome biology
по: Liang, Z
Опубликовано: (2022)

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii
по: Gorfu, Gezahegn, и др.
Опубликовано: (2014)

Inhibition of IκB Kinase at 24 hours after acute kidney injury improves recovery of renal function and attenuates fibrosis
по: Johnson, F, и др.
Опубликовано: (2017)

Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides
по: Verma, Chandra Shekhar, и др.
Опубликовано: (2019)

Mitochondrial redox modulation of NLRP3 inflammasome in differentiated THP-1 cells
по: Abas, Razif, и др.
Опубликовано: (2019)

Diabetic cardiac autonomic neuropathy: a review of NLRP3 inflammasome complicity
по: Subramaniam, Shamala Devi, и др.
Опубликовано: (2024)

Inflammasome Sensor NLRP1 Controls Rat Macrophage Susceptibility to Toxoplasma gondii
по: Cirelli, Kimberly, и др.
Опубликовано: (2014)

Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis
по: Robinson, Kim Samirah, и др.
Опубликовано: (2023)

Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome
по: Rozario, Pritisha, и др.
Опубликовано: (2024)

The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists
по: Chen, KW, и др.
Опубликовано: (2016)

Adenovirus VA RNAI blocks ASC oligomerization and inhibits NLRP3 inflammasome activation
по: Darweesh, M, и др.
Опубликовано: (2019)

EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption
по: Pinilla, Miriam, и др.
Опубликовано: (2023)

TBK1- and IKKe-mediated control of NLRP3 inflammasome activation and regulation of cell death
по: Fischer, FA
Опубликовано: (2023)

Mycobacterium tuberculosis protein ESAT‐6 is a potent activator of the NLRP3/ASC inflammasome
по: Mishra, BB, и др.
Опубликовано: (2010)

Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals
по: Bezbradica, J, и др.
Опубликовано: (2016)

Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals
по: Coll, RC, и др.
Опубликовано: (2016)

A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation
по: Nizami, S, и др.
Опубликовано: (2021)

TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation
по: Fischer, FA, и др.
Опубликовано: (2021)

RvE1 attenuates polymicrobial sepsis-induced cardiac dysfunction and enhances bacterial clearance
по: Chen, J, и др.
Опубликовано: (2020)

The NLRP3 inflammasome in age-related cerebral small vessel disease manifestations: untying the innate immune response connection
по: Che Mohd Nassir, Che Mohd Nasril, и др.
Опубликовано: (2023)

Menhaden fish oil attenuates postpartum depression in rat model via inhibition of NLRP3-inflammasome driven inflammatory pathway
по: Abdul Aziz, Nurul Uyun, и др.
Опубликовано: (2021)

Bruton's tyrosine kinase regulates TLR7/8-induced TNF transcription via nuclear factor-κB recruitment
по: Page, T, и др.
Опубликовано: (2018)

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress
по: Lerner, Alana G., и др.
Опубликовано: (2017)

Richard Bruton outside the Irish Centre
по: London Irish Centre, LIC
Опубликовано: (1996)

Expression of Bruton's tyrosine kinase in osteoclasts
по: Danks, L, и др.
Опубликовано: (2005)

Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes
по: Purvis, G, и др.
Опубликовано: (2017)

PHOrming the inflammasome: phosphorylation is a critical switch in inflammasome signalling
по: McKee, CM, и др.
Опубликовано: (2021)

Identification of Annexina1 as an endogenous regulator of RhoA, and its role in the pathophysiology and experimental therapy of type-2 diabetes
по: Purvis, G, и др.
Опубликовано: (2019)

Neuroinﬂammation and COVID-19 ischemic stroke recovery—Evolving evidence for the mediating roles of the ACE2/angiotensin-(1–7)/mas receptor axis and NLRP3 inﬂammasome
по: Che Mohd Nasril, Che Mohd Nassir, и др.
Опубликовано: (2022)

Neuroinflammation and COVID-19 ischemic stroke recovery—Evolving evidence for the mediating roles of the ACE2/Angiotensin-(1–7)/Mas Receptor Axis and NLRP3 Inflammasome
по: Che Mohd Nasril, Che Mohd Nassir, и др.
Опубликовано: (2022)

Neuroinflammation and COVID-19 ischemic stroke recovery —evolving evidence for the mediating roles of ACE2/angiotensin-1a“7/Mas receptor axis and NLRP3 inflammasome
по: Che Mohd Nassir, Che Mohd Nasril, и др.
Опубликовано: (2022)

A synthetic peptide designed to neutralize lipopolysaccharides attenuates metaflammation and diet-induced metabolic derangements in mice
по: Mohammad, S, и др.
Опубликовано: (2021)

Inflammasomes as regulators of mechano-immunity
по: Bezbradica, JS, и др.
Опубликовано: (2023)

The role of inflammasomes in intestinal inflammation
по: Srinivasan, N
Опубликовано: (2014)

NF-κB-inducing kinase is dispensable for activation of NF-κB in inflammatory settings but essential for lymphotoxin β receptor activation of NF-κB in primary human fibroblasts
по: Smith, C, и др.
Опубликовано: (2001)

Rodent inflammasome activation by Toxoplasma gondii
по: Cirelli, Kimberly M
Опубликовано: (2016)