Tethered aminohydroxylation: synthesis of the β-amino acid of microsclerodermins A and B.

Tethered aminohydroxylation: synthesis of the β-amino acid of microsclerodermins A and B.

The utility of the tethered aminohydroxylation (TA) has been demonstrated by synthesis of the complex β-amino acid residue of microsclerodermins A and B. The TA provided a regio- and stereoselective functionalization of a complex homoallylic alcohol. The route includes late-stage introduction of the...

詳細記述

書誌詳細
主要な著者: Pullin, R, Rathi, A, Melikhova, E, Winter, C, Thompson, A, Donohoe, T
フォーマット: Journal article
言語:English
出版事項: 2013
その他の書誌記述
要約:The utility of the tethered aminohydroxylation (TA) has been demonstrated by synthesis of the complex β-amino acid residue of microsclerodermins A and B. The TA provided a regio- and stereoselective functionalization of a complex homoallylic alcohol. The route includes late-stage introduction of the aliphatic side chain via a cuprate addition and cross metathesis, a tactic designed to render the synthesis applicable to other microsclerodermins.

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