Tethered aminohydroxylation: synthesis of the β-amino acid of microsclerodermins A and B.

Tethered aminohydroxylation: synthesis of the β-amino acid of microsclerodermins A and B.

The utility of the tethered aminohydroxylation (TA) has been demonstrated by synthesis of the complex β-amino acid residue of microsclerodermins A and B. The TA provided a regio- and stereoselective functionalization of a complex homoallylic alcohol. The route includes late-stage introduction of the...

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書目詳細資料
Main Authors: Pullin, R, Rathi, A, Melikhova, E, Winter, C, Thompson, A, Donohoe, T
格式: Journal article
語言:English
出版: 2013
實物特徵
總結:The utility of the tethered aminohydroxylation (TA) has been demonstrated by synthesis of the complex β-amino acid residue of microsclerodermins A and B. The TA provided a regio- and stereoselective functionalization of a complex homoallylic alcohol. The route includes late-stage introduction of the aliphatic side chain via a cuprate addition and cross metathesis, a tactic designed to render the synthesis applicable to other microsclerodermins.

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