Tethered aminohydroxylation: synthesis of the β-amino acid of microsclerodermins A and B.
The utility of the tethered aminohydroxylation (TA) has been demonstrated by synthesis of the complex β-amino acid residue of microsclerodermins A and B. The TA provided a regio- and stereoselective functionalization of a complex homoallylic alcohol. The route includes late-stage introduction of the...
| मुख्य लेखकों: | , , , , , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2013
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| _version_ | 1826304329600991232 |
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| author | Pullin, R Rathi, A Melikhova, E Winter, C Thompson, A Donohoe, T |
| author_facet | Pullin, R Rathi, A Melikhova, E Winter, C Thompson, A Donohoe, T |
| author_sort | Pullin, R |
| collection | OXFORD |
| description | The utility of the tethered aminohydroxylation (TA) has been demonstrated by synthesis of the complex β-amino acid residue of microsclerodermins A and B. The TA provided a regio- and stereoselective functionalization of a complex homoallylic alcohol. The route includes late-stage introduction of the aliphatic side chain via a cuprate addition and cross metathesis, a tactic designed to render the synthesis applicable to other microsclerodermins. |
| first_indexed | 2024-03-07T06:16:10Z |
| format | Journal article |
| id | oxford-uuid:f125db59-e57e-402c-928f-1501e40a41c5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:16:10Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:f125db59-e57e-402c-928f-1501e40a41c52022-03-27T11:53:50ZTethered aminohydroxylation: synthesis of the β-amino acid of microsclerodermins A and B.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f125db59-e57e-402c-928f-1501e40a41c5EnglishSymplectic Elements at Oxford2013Pullin, RRathi, AMelikhova, EWinter, CThompson, ADonohoe, TThe utility of the tethered aminohydroxylation (TA) has been demonstrated by synthesis of the complex β-amino acid residue of microsclerodermins A and B. The TA provided a regio- and stereoselective functionalization of a complex homoallylic alcohol. The route includes late-stage introduction of the aliphatic side chain via a cuprate addition and cross metathesis, a tactic designed to render the synthesis applicable to other microsclerodermins. |
| spellingShingle | Pullin, R Rathi, A Melikhova, E Winter, C Thompson, A Donohoe, T Tethered aminohydroxylation: synthesis of the β-amino acid of microsclerodermins A and B. |
| title | Tethered aminohydroxylation: synthesis of the β-amino acid of microsclerodermins A and B. |
| title_full | Tethered aminohydroxylation: synthesis of the β-amino acid of microsclerodermins A and B. |
| title_fullStr | Tethered aminohydroxylation: synthesis of the β-amino acid of microsclerodermins A and B. |
| title_full_unstemmed | Tethered aminohydroxylation: synthesis of the β-amino acid of microsclerodermins A and B. |
| title_short | Tethered aminohydroxylation: synthesis of the β-amino acid of microsclerodermins A and B. |
| title_sort | tethered aminohydroxylation synthesis of the β amino acid of microsclerodermins a and b |
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