The vascular targeting agent combretastatin A-4-phosphate induces neutrophil recruitment to endothelial cells in vitro.

BACKGROUND: Combretastatin A-4-phosphate (CA-4-P) is a microtubule depolymerising agent currently in clinical trial as a tumour vascular-targeting agent. In vivo, CA-4-P causes rapid shutdown of tumour blood flow (within minutes) and a significant neutrophil infiltration at later times. MATERIALS A...

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Príomhchruthaitheoirí: Brooks, A, Kanthou, C, Cook, I, Tozer, G, Barber, P, Vojnovic, B, Nash, G, Parkins, C
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2003