Regulatory T cells in the control of immune pathology.
It is now well established that regulatory T (T(R)) cells can inhibit harmful immunopathological responses directed against self or foreign antigens. However, many key aspects of T(R) cell biology remain unresolved, especially with regard to their antigen specificities and the cellular and molecular...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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| _version_ | 1826304346418053120 |
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| author | Maloy, K Powrie, F |
| author_facet | Maloy, K Powrie, F |
| author_sort | Maloy, K |
| collection | OXFORD |
| description | It is now well established that regulatory T (T(R)) cells can inhibit harmful immunopathological responses directed against self or foreign antigens. However, many key aspects of T(R) cell biology remain unresolved, especially with regard to their antigen specificities and the cellular and molecular pathways involved in their development and mechanisms of action. We will review here recent findings in these areas, outline a model for how T(R) cells may inhibit the development of immune pathology and discuss potential therapeutic benefits that may arise from the manipulation of T(R) cell function. |
| first_indexed | 2024-03-07T06:16:25Z |
| format | Journal article |
| id | oxford-uuid:f1398760-1a20-4964-a74c-655bb06ea988 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:16:25Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:f1398760-1a20-4964-a74c-655bb06ea9882022-03-27T11:54:23ZRegulatory T cells in the control of immune pathology.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f1398760-1a20-4964-a74c-655bb06ea988EnglishSymplectic Elements at Oxford2001Maloy, KPowrie, FIt is now well established that regulatory T (T(R)) cells can inhibit harmful immunopathological responses directed against self or foreign antigens. However, many key aspects of T(R) cell biology remain unresolved, especially with regard to their antigen specificities and the cellular and molecular pathways involved in their development and mechanisms of action. We will review here recent findings in these areas, outline a model for how T(R) cells may inhibit the development of immune pathology and discuss potential therapeutic benefits that may arise from the manipulation of T(R) cell function. |
| spellingShingle | Maloy, K Powrie, F Regulatory T cells in the control of immune pathology. |
| title | Regulatory T cells in the control of immune pathology. |
| title_full | Regulatory T cells in the control of immune pathology. |
| title_fullStr | Regulatory T cells in the control of immune pathology. |
| title_full_unstemmed | Regulatory T cells in the control of immune pathology. |
| title_short | Regulatory T cells in the control of immune pathology. |
| title_sort | regulatory t cells in the control of immune pathology |
| work_keys_str_mv | AT maloyk regulatorytcellsinthecontrolofimmunepathology AT powrief regulatorytcellsinthecontrolofimmunepathology |