Differential escape patterns within the dominant HLA-B*57:03-restricted HIV Gag epitope reflect distinct clade-specific functional constraints.

Differential escape patterns within the dominant HLA-B*57:03-restricted HIV Gag epitope reflect distinct clade-specific functional constraints.

UNLABELLED: HLA-B*57:01 and HLA-B*57:03, the most prevalent HLA-B*57 subtypes in Caucasian and African populations, respectively, are the HLA alleles most protective against HIV disease progression. Understanding the mechanisms underlying this immune control is of critical importance, yet they remai...

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Bibliographic Details
Main Authors: Payne, R, Branch, S, Kløverpris, H, Matthews, P, Koofhethile, C, Strong, T, Adland, E, Leitman, E, Frater, J, Ndung'u, T, Hunter, E, Haubrich, R, Mothe, B, Edwards, A, Riddell, L, Chen, F, Harrigan, P, Brumme, Z, Mallal, S, John, M, Jooste, J, Shapiro, R, Deeks, S, Walker, B, Brander, C
Format: Journal article
Language:English
Published: American Society for Microbiology 2014

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