Polymorphisms in the human inhibitory signal-regulatory protein α do not affect binding to its ligand CD47.
CD47 is a widely distributed membrane protein that interacts with signal-regulatory protein α (SIRPα), an inhibitory receptor on myeloid cells that gives a "don't-eat-me" signal. Manipulation of the interaction is of considerable interest in the immunotherapy of cancer and in xenotran...
প্রধান লেখক: | Hatherley, D, Lea, S, Johnson, S, Barclay, N |
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বিন্যাস: | Journal article |
ভাষা: | English |
প্রকাশিত: |
American Society for Biochemistry and Molecular Biology Inc.
2014
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অনুরূপ উপাদানগুলি
অনুরূপ উপাদানগুলি
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Signal-regulatory protein α from the NOD mouse binds human CD47 with an exceptionally high affinity-- implications for engraftment of human cells.
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Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.
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CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPα1
অনুযায়ী: Vernon-Wilson, E, অন্যান্য
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Structure of a complex of CD47 and the paired receptor SIRP alpha reveals a mechanism for ligand discrimination
অনুযায়ী: Hatherley, D, অন্যান্য
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Signal regulatory protein alpha (SIRPalpha)/CD47 interaction and function.
অনুযায়ী: Barclay, N
প্রকাশিত: (2009)