Polymorphisms in the human inhibitory signal-regulatory protein α do not affect binding to its ligand CD47.
CD47 is a widely distributed membrane protein that interacts with signal-regulatory protein α (SIRPα), an inhibitory receptor on myeloid cells that gives a "don't-eat-me" signal. Manipulation of the interaction is of considerable interest in the immunotherapy of cancer and in xenotran...
| Auteurs principaux: | , , , |
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| Format: | Journal article |
| Langue: | English |
| Publié: |
American Society for Biochemistry and Molecular Biology Inc.
2014
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