Polymorphisms in the human inhibitory signal-regulatory protein α do not affect binding to its ligand CD47.

CD47 is a widely distributed membrane protein that interacts with signal-regulatory protein α (SIRPα), an inhibitory receptor on myeloid cells that gives a "don't-eat-me" signal. Manipulation of the interaction is of considerable interest in the immunotherapy of cancer and in xenotran...

詳細記述

書誌詳細
主要な著者: Hatherley, D, Lea, S, Johnson, S, Barclay, N
フォーマット: Journal article
言語:English
出版事項: American Society for Biochemistry and Molecular Biology Inc. 2014