The structure and function of the T3-Ti molecular complex on human T lymphocytes.
Recent studies using cloned antigen-specific T lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to identification of the human T cell antigen receptor as a surface complex composed of a clonotypic 90-kDa Ti heterodimer and the invariant 20- and...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1986
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| _version_ | 1797103214407974912 |
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| author | Reinherz, E Royer, H Campen, T Ramarli, D Chang, H Acuto, O |
| author_facet | Reinherz, E Royer, H Campen, T Ramarli, D Chang, H Acuto, O |
| author_sort | Reinherz, E |
| collection | OXFORD |
| description | Recent studies using cloned antigen-specific T lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to identification of the human T cell antigen receptor as a surface complex composed of a clonotypic 90-kDa Ti heterodimer and the invariant 20- and 25-kDa T3 molecules. Approximately 30,000-40,000 Ti and T3 molecules exist on the surface of human T lymphocytes. These glycoproteins are acquired and expressed during late thymic ontogeny, thus providing the structural basis for immunologic competence. The Ti alpha and Ti beta subunits bear no precursor-to-product relationship and are encoded by separate germ line V, D, J, and C segments, which rearrange during intrathymic differentiation to form an active gene set. Triggering of the T3-Ti receptor complex induces a rapid increase in free cytoplasmic Ca2+ and gives rise to specific antigen-induced proliferation through an autocrine pathway involving endogenous IL 2 production, release, and subsequent binding to IL 2 receptors. |
| first_indexed | 2024-03-07T06:16:53Z |
| format | Journal article |
| id | oxford-uuid:f161d994-a6d5-4ce8-9f2a-1d60594cb72b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:16:53Z |
| publishDate | 1986 |
| record_format | dspace |
| spelling | oxford-uuid:f161d994-a6d5-4ce8-9f2a-1d60594cb72b2022-03-27T11:55:35ZThe structure and function of the T3-Ti molecular complex on human T lymphocytes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f161d994-a6d5-4ce8-9f2a-1d60594cb72bEnglishSymplectic Elements at Oxford1986Reinherz, ERoyer, HCampen, TRamarli, DChang, HAcuto, ORecent studies using cloned antigen-specific T lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to identification of the human T cell antigen receptor as a surface complex composed of a clonotypic 90-kDa Ti heterodimer and the invariant 20- and 25-kDa T3 molecules. Approximately 30,000-40,000 Ti and T3 molecules exist on the surface of human T lymphocytes. These glycoproteins are acquired and expressed during late thymic ontogeny, thus providing the structural basis for immunologic competence. The Ti alpha and Ti beta subunits bear no precursor-to-product relationship and are encoded by separate germ line V, D, J, and C segments, which rearrange during intrathymic differentiation to form an active gene set. Triggering of the T3-Ti receptor complex induces a rapid increase in free cytoplasmic Ca2+ and gives rise to specific antigen-induced proliferation through an autocrine pathway involving endogenous IL 2 production, release, and subsequent binding to IL 2 receptors. |
| spellingShingle | Reinherz, E Royer, H Campen, T Ramarli, D Chang, H Acuto, O The structure and function of the T3-Ti molecular complex on human T lymphocytes. |
| title | The structure and function of the T3-Ti molecular complex on human T lymphocytes. |
| title_full | The structure and function of the T3-Ti molecular complex on human T lymphocytes. |
| title_fullStr | The structure and function of the T3-Ti molecular complex on human T lymphocytes. |
| title_full_unstemmed | The structure and function of the T3-Ti molecular complex on human T lymphocytes. |
| title_short | The structure and function of the T3-Ti molecular complex on human T lymphocytes. |
| title_sort | structure and function of the t3 ti molecular complex on human t lymphocytes |
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