Mesopic and dark-adapted two-color fundus-controlled perimetry in geographic atrophy secondary to age-related macular degeneration
<p><strong>PURPOSE:</strong> To investigate retinal sensitivity in the junctional zone of geographic atrophy (GA) secondary to age-related macular degeneration using patient-tailored perimetry grids for mesopic and dark-adapted two-color fundus-controlled perimetry.</p> <...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Lippincott, Williams & Wilkins
2018
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| _version_ | 1797103215004614656 |
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| author | Pfau, M Müller, PL von der Emde, L Lindner, M Möller, PT Fleckenstein, M Holz, FG Schmitz-Valckenberg, S |
| author_facet | Pfau, M Müller, PL von der Emde, L Lindner, M Möller, PT Fleckenstein, M Holz, FG Schmitz-Valckenberg, S |
| author_sort | Pfau, M |
| collection | OXFORD |
| description | <p><strong>PURPOSE:</strong> To investigate retinal sensitivity in the junctional zone of geographic atrophy (GA) secondary to age-related macular degeneration using patient-tailored perimetry grids for mesopic and dark-adapted two-color fundus-controlled perimetry.</p>
<p><strong>METHODS:</strong> Twenty-five eyes with GA of 25 patients (prospective, natural-history Directional Spread in Geographic Atrophy study [DSGA; NCT02051998]) and 40 eyes of 40 normal subjects were included. Patient-tailored perimetry grids were generated using annotated fundus autofluorescence data. Customized software positioned test-points along iso-hulls surrounding the GA boundary at distances of 0.43°, 0.86°, 1.29°, 2.15°, and 3.01°. The grids were used for duplicate mesopic and dark-adapted two-color (cyan and red) fundus-controlled perimetry. Age-adjusted reference-data were obtained through regression analysis of normative data followed by spatial interpolation.</p>
<p><strong>RESULTS:</strong> The mean sensitivity loss for mesopic testing decreased with the distance to GA (-10.3 dB [0.43°], -8.2 dB [0.86°], -7.1 dB [1.29°], -6.8 dB [2.15°], and -6.6 dB [3.01°]; P < 0.01). Dark-adapted cyan sensitivity loss exceeded dark-adapted red sensitivity loss for all iso-hulls (-14.8 vs. -11.7 dB, -13.5 vs. -10.1 dB, -12.8 vs. -9.1 dB, -11.6 vs. -8.2 dB, -10.7 vs. -8.0 dB; P < 0.01).</p>
<p><strong>CONCLUSION:</strong> Patient-tailored fundus-controlled perimetry grids allowed for testing of retinal function in the junctional zone of GA with high spatial resolution. A distinct decrease in mesopic sensitivity loss between 0.43° (125 µm) and 1.29° (375 µm) was observed that leveled off at more distant test-points. In proximity to the GA boundary, the results indicate that rod exceeded cone dysfunction.</p> |
| first_indexed | 2024-03-07T06:16:53Z |
| format | Journal article |
| id | oxford-uuid:f16268c0-83be-48cd-a3e6-f341f6dbd1c7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:16:53Z |
| publishDate | 2018 |
| publisher | Lippincott, Williams & Wilkins |
| record_format | dspace |
| spelling | oxford-uuid:f16268c0-83be-48cd-a3e6-f341f6dbd1c72022-03-27T11:55:47ZMesopic and dark-adapted two-color fundus-controlled perimetry in geographic atrophy secondary to age-related macular degenerationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f16268c0-83be-48cd-a3e6-f341f6dbd1c7EnglishSymplectic ElementsLippincott, Williams & Wilkins 2018Pfau, MMüller, PLvon der Emde, LLindner, MMöller, PTFleckenstein, MHolz, FGSchmitz-Valckenberg, S<p><strong>PURPOSE:</strong> To investigate retinal sensitivity in the junctional zone of geographic atrophy (GA) secondary to age-related macular degeneration using patient-tailored perimetry grids for mesopic and dark-adapted two-color fundus-controlled perimetry.</p> <p><strong>METHODS:</strong> Twenty-five eyes with GA of 25 patients (prospective, natural-history Directional Spread in Geographic Atrophy study [DSGA; NCT02051998]) and 40 eyes of 40 normal subjects were included. Patient-tailored perimetry grids were generated using annotated fundus autofluorescence data. Customized software positioned test-points along iso-hulls surrounding the GA boundary at distances of 0.43°, 0.86°, 1.29°, 2.15°, and 3.01°. The grids were used for duplicate mesopic and dark-adapted two-color (cyan and red) fundus-controlled perimetry. Age-adjusted reference-data were obtained through regression analysis of normative data followed by spatial interpolation.</p> <p><strong>RESULTS:</strong> The mean sensitivity loss for mesopic testing decreased with the distance to GA (-10.3 dB [0.43°], -8.2 dB [0.86°], -7.1 dB [1.29°], -6.8 dB [2.15°], and -6.6 dB [3.01°]; P < 0.01). Dark-adapted cyan sensitivity loss exceeded dark-adapted red sensitivity loss for all iso-hulls (-14.8 vs. -11.7 dB, -13.5 vs. -10.1 dB, -12.8 vs. -9.1 dB, -11.6 vs. -8.2 dB, -10.7 vs. -8.0 dB; P < 0.01).</p> <p><strong>CONCLUSION:</strong> Patient-tailored fundus-controlled perimetry grids allowed for testing of retinal function in the junctional zone of GA with high spatial resolution. A distinct decrease in mesopic sensitivity loss between 0.43° (125 µm) and 1.29° (375 µm) was observed that leveled off at more distant test-points. In proximity to the GA boundary, the results indicate that rod exceeded cone dysfunction.</p> |
| spellingShingle | Pfau, M Müller, PL von der Emde, L Lindner, M Möller, PT Fleckenstein, M Holz, FG Schmitz-Valckenberg, S Mesopic and dark-adapted two-color fundus-controlled perimetry in geographic atrophy secondary to age-related macular degeneration |
| title | Mesopic and dark-adapted two-color fundus-controlled perimetry in geographic atrophy secondary to age-related macular degeneration |
| title_full | Mesopic and dark-adapted two-color fundus-controlled perimetry in geographic atrophy secondary to age-related macular degeneration |
| title_fullStr | Mesopic and dark-adapted two-color fundus-controlled perimetry in geographic atrophy secondary to age-related macular degeneration |
| title_full_unstemmed | Mesopic and dark-adapted two-color fundus-controlled perimetry in geographic atrophy secondary to age-related macular degeneration |
| title_short | Mesopic and dark-adapted two-color fundus-controlled perimetry in geographic atrophy secondary to age-related macular degeneration |
| title_sort | mesopic and dark adapted two color fundus controlled perimetry in geographic atrophy secondary to age related macular degeneration |
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