303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

Nitric oxide (NO), produced by endothelial NO synthase (NOS) is a key regulator of vascular tone and blood pressure. Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial NOS. When BH4 levels become limiting, eNOS produces superoxide anion rather than NO and in turn further reduces NO b...

书目详细资料
Main Authors:	Chuaiphichai, S, Mcneill, E, Douglas, G, Crabtree, M, Bendall, J, Hale, A, Alp, N, Channon, K
格式:	Journal article
语言:	English
出版:	2014

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