Growth hormone, insulin-like growth factor-I and its binding proteins in the follow-up of acromegaly.
Elevated growth hormone is a cardinal feature of acromegaly from the biological view point. Growth hormone stimulates IGF-I secretion and that of its major binding protein IGFBP-3. In these circumstances, where hyperinsulinaemia is present, IGFBP-1 levels, which are inversely related to insulin, are...
| Tác giả chính: | |
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| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
1997
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| _version_ | 1826304392752529408 |
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| author | Wass, J |
| author_facet | Wass, J |
| author_sort | Wass, J |
| collection | OXFORD |
| description | Elevated growth hormone is a cardinal feature of acromegaly from the biological view point. Growth hormone stimulates IGF-I secretion and that of its major binding protein IGFBP-3. In these circumstances, where hyperinsulinaemia is present, IGFBP-1 levels, which are inversely related to insulin, are suppressed. Failure of suppression of growth hormone after oral glucose (> 2 mU/l (1 microgram/l) is the cardinal biochemical feature of acromegaly. IGF-I values at diagnosis are almost invariably raised. There is some overlap in the value of basal IGFBP-3 between normal subjects and acromegalics. For monitoring purposes, growth hormone values, either basal or during the day are useful. There is overlap in the values of IGF-I and IGFBP-3 between normal subjects and patients on treatment. Prognosis in acromegaly is determined by persistent elevation of growth hormone levels above 5 mU/l (2.5 micrograms/ l). More data are required for the prognostic use of IGF-I. |
| first_indexed | 2024-03-07T06:17:07Z |
| format | Journal article |
| id | oxford-uuid:f172cea7-062e-4e37-89d0-80dd8e03721a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:17:07Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:f172cea7-062e-4e37-89d0-80dd8e03721a2022-03-27T11:56:04ZGrowth hormone, insulin-like growth factor-I and its binding proteins in the follow-up of acromegaly.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f172cea7-062e-4e37-89d0-80dd8e03721aEnglishSymplectic Elements at Oxford1997Wass, JElevated growth hormone is a cardinal feature of acromegaly from the biological view point. Growth hormone stimulates IGF-I secretion and that of its major binding protein IGFBP-3. In these circumstances, where hyperinsulinaemia is present, IGFBP-1 levels, which are inversely related to insulin, are suppressed. Failure of suppression of growth hormone after oral glucose (> 2 mU/l (1 microgram/l) is the cardinal biochemical feature of acromegaly. IGF-I values at diagnosis are almost invariably raised. There is some overlap in the value of basal IGFBP-3 between normal subjects and acromegalics. For monitoring purposes, growth hormone values, either basal or during the day are useful. There is overlap in the values of IGF-I and IGFBP-3 between normal subjects and patients on treatment. Prognosis in acromegaly is determined by persistent elevation of growth hormone levels above 5 mU/l (2.5 micrograms/ l). More data are required for the prognostic use of IGF-I. |
| spellingShingle | Wass, J Growth hormone, insulin-like growth factor-I and its binding proteins in the follow-up of acromegaly. |
| title | Growth hormone, insulin-like growth factor-I and its binding proteins in the follow-up of acromegaly. |
| title_full | Growth hormone, insulin-like growth factor-I and its binding proteins in the follow-up of acromegaly. |
| title_fullStr | Growth hormone, insulin-like growth factor-I and its binding proteins in the follow-up of acromegaly. |
| title_full_unstemmed | Growth hormone, insulin-like growth factor-I and its binding proteins in the follow-up of acromegaly. |
| title_short | Growth hormone, insulin-like growth factor-I and its binding proteins in the follow-up of acromegaly. |
| title_sort | growth hormone insulin like growth factor i and its binding proteins in the follow up of acromegaly |
| work_keys_str_mv | AT wassj growthhormoneinsulinlikegrowthfactorianditsbindingproteinsinthefollowupofacromegaly |