CD7 expression distinguishes subsets of CD4(+) T cells with distinct functional properties and ability to support replication of HIV-1.
Enrichment of a subset of CD4(+)CD45R0(+)CD7(-) T cells has been observed in HIV-infected individuals. We have investigated the ability of CD7(+) and CD7(-) T cells to support replication of HIV and show that virus replicates preferentially in CD7(+) cells. Several possible mechanisms that may under...
| Autores principales: | , , , , , , , |
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| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
2000
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| _version_ | 1826304396718243840 |
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| author | Wallace, D Matear, P Davies, D Hicks, R Lebosse, C Eyeson, J Beverley, P Vyakarnam, A |
| author_facet | Wallace, D Matear, P Davies, D Hicks, R Lebosse, C Eyeson, J Beverley, P Vyakarnam, A |
| author_sort | Wallace, D |
| collection | OXFORD |
| description | Enrichment of a subset of CD4(+)CD45R0(+)CD7(-) T cells has been observed in HIV-infected individuals. We have investigated the ability of CD7(+) and CD7(-) T cells to support replication of HIV and show that virus replicates preferentially in CD7(+) cells. Several possible mechanisms that may underlie such differences in susceptibility to HIV were studied. Our data demonstrate that mitogen stimulation induces poor expression of CD25 and IL-2 in CD7(-) compared with CD7(+) cells. We also show that uninfected CD7(-) cells are more resistant to mitogen-induced apoptosis than CD7(+) cells. Our data support the view that the CD7(-) subset is inherently resistant to HIV replication and that this is due in part to reduced CD25 expression and IL-2 production. |
| first_indexed | 2024-03-07T06:17:10Z |
| format | Journal article |
| id | oxford-uuid:f1786dee-92fe-478b-ae0a-a891e204ae3f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:17:10Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:f1786dee-92fe-478b-ae0a-a891e204ae3f2022-03-27T11:56:17ZCD7 expression distinguishes subsets of CD4(+) T cells with distinct functional properties and ability to support replication of HIV-1.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f1786dee-92fe-478b-ae0a-a891e204ae3fEnglishSymplectic Elements at Oxford2000Wallace, DMatear, PDavies, DHicks, RLebosse, CEyeson, JBeverley, PVyakarnam, AEnrichment of a subset of CD4(+)CD45R0(+)CD7(-) T cells has been observed in HIV-infected individuals. We have investigated the ability of CD7(+) and CD7(-) T cells to support replication of HIV and show that virus replicates preferentially in CD7(+) cells. Several possible mechanisms that may underlie such differences in susceptibility to HIV were studied. Our data demonstrate that mitogen stimulation induces poor expression of CD25 and IL-2 in CD7(-) compared with CD7(+) cells. We also show that uninfected CD7(-) cells are more resistant to mitogen-induced apoptosis than CD7(+) cells. Our data support the view that the CD7(-) subset is inherently resistant to HIV replication and that this is due in part to reduced CD25 expression and IL-2 production. |
| spellingShingle | Wallace, D Matear, P Davies, D Hicks, R Lebosse, C Eyeson, J Beverley, P Vyakarnam, A CD7 expression distinguishes subsets of CD4(+) T cells with distinct functional properties and ability to support replication of HIV-1. |
| title | CD7 expression distinguishes subsets of CD4(+) T cells with distinct functional properties and ability to support replication of HIV-1. |
| title_full | CD7 expression distinguishes subsets of CD4(+) T cells with distinct functional properties and ability to support replication of HIV-1. |
| title_fullStr | CD7 expression distinguishes subsets of CD4(+) T cells with distinct functional properties and ability to support replication of HIV-1. |
| title_full_unstemmed | CD7 expression distinguishes subsets of CD4(+) T cells with distinct functional properties and ability to support replication of HIV-1. |
| title_short | CD7 expression distinguishes subsets of CD4(+) T cells with distinct functional properties and ability to support replication of HIV-1. |
| title_sort | cd7 expression distinguishes subsets of cd4 t cells with distinct functional properties and ability to support replication of hiv 1 |
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