CD7 expression distinguishes subsets of CD4(+) T cells with distinct functional properties and ability to support replication of HIV-1.

CD7 expression distinguishes subsets of CD4(+) T cells with distinct functional properties and ability to support replication of HIV-1.

Enrichment of a subset of CD4(+)CD45R0(+)CD7(-) T cells has been observed in HIV-infected individuals. We have investigated the ability of CD7(+) and CD7(-) T cells to support replication of HIV and show that virus replicates preferentially in CD7(+) cells. Several possible mechanisms that may under...

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Bibliographic Details
Main Authors: Wallace, D, Matear, P, Davies, D, Hicks, R, Lebosse, C, Eyeson, J, Beverley, P, Vyakarnam, A
Format: Journal article
Language:English
Published: 2000

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