Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class.

ABL2 (also known as ARG (ABL related gene)) is closely related to the well-studied Abelson kinase cABL. ABL2 is involved in human neoplastic diseases and is deregulated in solid tumors. Oncogenic gene translocations occur in acute leukemia. So far no structural information for ABL2 has been reported...

詳細記述

書誌詳細
主要な著者:	Salah, E, Ugochukwu, E, Barr, A, von Delft, F, Knapp, S, Elkins, J
フォーマット:	Journal article
言語:	English
出版事項:	2011
主題:	Protein-Tyrosine Kinases chemistry Models, Molecular Crystallography, X-Ray Amino Acid Motifs Protein Structure, Tertiary Triazoles pharmacology Protein Binding metabolism Pyrimidines Piperazines Protein Kinase Inhibitors antagonists and inhibitors

Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class.

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