Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class.

Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class.

Näytä muut versiot (1)

ABL2 (also known as ARG (ABL related gene)) is closely related to the well-studied Abelson kinase cABL. ABL2 is involved in human neoplastic diseases and is deregulated in solid tumors. Oncogenic gene translocations occur in acute leukemia. So far no structural information for ABL2 has been reported...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Salah, E, Ugochukwu, E, Barr, A, von Delft, F, Knapp, S, Elkins, J
Aineistotyyppi: Journal article
Kieli:English
Julkaistu: 2011
Aiheet:
Protein-Tyrosine Kinases
chemistry
Models, Molecular
Crystallography, X-Ray
Amino Acid Motifs
Protein Structure, Tertiary
Triazoles
pharmacology
Protein Binding
metabolism
Pyrimidines
Piperazines
Protein Kinase Inhibitors
antagonists and inhibitors

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