Temporal association of acute hepatitis A and Plasmodium falciparum malaria in children.
BACKGROUND: In sub-Saharan Africa, Plasmodium falciparum and hepatitis A (HAV) infections are common, especially in children. Co-infections with these two pathogens may therefore occur, but it is unknown if temporal clustering exists. MATERIALS AND METHODS: We studied the pattern of co-infection of...
| Autores principales: | , , , , , , , |
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| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
2011
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| _version_ | 1826304416317177856 |
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| author | Klein Klouwenberg, P Sasi, P Bashraheil, M Awuondo, K Bonten, M Berkley, J Marsh, K Borrmann, S |
| author_facet | Klein Klouwenberg, P Sasi, P Bashraheil, M Awuondo, K Bonten, M Berkley, J Marsh, K Borrmann, S |
| author_sort | Klein Klouwenberg, P |
| collection | OXFORD |
| description | BACKGROUND: In sub-Saharan Africa, Plasmodium falciparum and hepatitis A (HAV) infections are common, especially in children. Co-infections with these two pathogens may therefore occur, but it is unknown if temporal clustering exists. MATERIALS AND METHODS: We studied the pattern of co-infection of P. falciparum malaria and acute HAV in Kenyan children under the age of 5 years in a cohort of children presenting with uncomplicated P. falciparum malaria. HAV status was determined during a 3-month follow-up period. DISCUSSION: Among 222 cases of uncomplicated malaria, 10 patients were anti-HAV IgM positive. The incidence of HAV infections during P. falciparum malaria was 1.7 (95% CI 0.81-3.1) infections/person-year while the cumulative incidence of HAV over the 3-month follow-up period was 0.27 (95% CI 0.14-0.50) infections/person-year. Children with or without HAV co-infections had similar mean P. falciparum asexual parasite densities at presentation (31,000/µL vs. 34,000/µL, respectively), largely exceeding the pyrogenic threshold of 2,500 parasites/µL in this population and minimizing risk of over-diagnosis of malaria as an explanation. CONCLUSION: The observed temporal association between acute HAV and P. falciparum malaria suggests that co-infections of these two hepatotrophic human pathogens may result from changes in host susceptibility. Testing this hypothesis will require larger prospective studies. |
| first_indexed | 2024-03-07T06:17:28Z |
| format | Journal article |
| id | oxford-uuid:f195afde-4cc0-41ad-a9ac-dbca352571f5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:17:28Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:f195afde-4cc0-41ad-a9ac-dbca352571f52022-03-27T11:57:05ZTemporal association of acute hepatitis A and Plasmodium falciparum malaria in children.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f195afde-4cc0-41ad-a9ac-dbca352571f5EnglishSymplectic Elements at Oxford2011Klein Klouwenberg, PSasi, PBashraheil, MAwuondo, KBonten, MBerkley, JMarsh, KBorrmann, S BACKGROUND: In sub-Saharan Africa, Plasmodium falciparum and hepatitis A (HAV) infections are common, especially in children. Co-infections with these two pathogens may therefore occur, but it is unknown if temporal clustering exists. MATERIALS AND METHODS: We studied the pattern of co-infection of P. falciparum malaria and acute HAV in Kenyan children under the age of 5 years in a cohort of children presenting with uncomplicated P. falciparum malaria. HAV status was determined during a 3-month follow-up period. DISCUSSION: Among 222 cases of uncomplicated malaria, 10 patients were anti-HAV IgM positive. The incidence of HAV infections during P. falciparum malaria was 1.7 (95% CI 0.81-3.1) infections/person-year while the cumulative incidence of HAV over the 3-month follow-up period was 0.27 (95% CI 0.14-0.50) infections/person-year. Children with or without HAV co-infections had similar mean P. falciparum asexual parasite densities at presentation (31,000/µL vs. 34,000/µL, respectively), largely exceeding the pyrogenic threshold of 2,500 parasites/µL in this population and minimizing risk of over-diagnosis of malaria as an explanation. CONCLUSION: The observed temporal association between acute HAV and P. falciparum malaria suggests that co-infections of these two hepatotrophic human pathogens may result from changes in host susceptibility. Testing this hypothesis will require larger prospective studies. |
| spellingShingle | Klein Klouwenberg, P Sasi, P Bashraheil, M Awuondo, K Bonten, M Berkley, J Marsh, K Borrmann, S Temporal association of acute hepatitis A and Plasmodium falciparum malaria in children. |
| title | Temporal association of acute hepatitis A and Plasmodium falciparum malaria in children. |
| title_full | Temporal association of acute hepatitis A and Plasmodium falciparum malaria in children. |
| title_fullStr | Temporal association of acute hepatitis A and Plasmodium falciparum malaria in children. |
| title_full_unstemmed | Temporal association of acute hepatitis A and Plasmodium falciparum malaria in children. |
| title_short | Temporal association of acute hepatitis A and Plasmodium falciparum malaria in children. |
| title_sort | temporal association of acute hepatitis a and plasmodium falciparum malaria in children |
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