Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

Inducible nitric oxide synthase (iNOS) plays a crucial role in controlling growth of Mycobacterium tuberculosis (M.tb), presumably via nitric oxide (NO) mediated killing. Here we show that leukocyte-specific deficiency of NO production, through targeted loss of the iNOS cofactor tetrahydrobiopteri...

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Bibliographic Details
Main Authors:	McNeill, E, Stylianou, E, Crabtree, M, Harrington-Kandt, RL, Kolb, AL, Diotallevi, M, Hale, A, Bettencourt, PJG, Tanner, R, O'Shea, M, Matsumiya, M, Lockstone, H, Muller, J, Fletcher, H, Greaves, D, McShane, H, Channon, K
Format:	Journal article
Published:	Springer Nature 2018

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