Engineering enzyme-cleavable oligonucleotides by automated solid-phase incorporation of cathepsin B sensitive dipeptide linkers
Oligonucleotides containing cleavable linkers have emerged as versatile tools to achieve stimulus-responsive and site-specific cleavage of DNA. However, the limitations of previously reported cleavable linkers including photolabile and disulfide linkers have restricted their applications in vivo . I...
Main Authors: | Jin, C, Sagheer, AHE, Li, S, Vallis, KA, Tan, W, Brown, T |
---|---|
Format: | Journal article |
Language: | English |
Published: |
Wiley
2022
|
Similar Items
-
Modular and automated synthesis of oligonucleotide-small molecule conjugates for cathepsin B mediated traceless release of payloads † ‡
by: Jin, C, et al.
Published: (2024) -
Expanding the Scope of the Cleavable <i>N</i>-(Methoxy)oxazolidine Linker for the Synthesis of Oligonucleotide Conjugates
by: Aapo Aho, et al.
Published: (2021-01-01) -
Cathepsin B-Cleavable Cyclopeptidic Chemotherapeutic Prodrugs
by: Viktorija Herceg, et al.
Published: (2020-09-01) -
Lysosomal-Cleavable Peptide Linkers in Antibody–Drug Conjugates
by: Seetharamsing Balamkundu, et al.
Published: (2023-11-01) -
Application of Cleavable Linkers to Improve Therapeutic Index of Radioligand Therapies
by: Joseph Lau, et al.
Published: (2022-08-01)