Engineering enzyme-cleavable oligonucleotides by automated solid-phase incorporation of cathepsin B sensitive dipeptide linkers
Oligonucleotides containing cleavable linkers have emerged as versatile tools to achieve stimulus-responsive and site-specific cleavage of DNA. However, the limitations of previously reported cleavable linkers including photolabile and disulfide linkers have restricted their applications in vivo . I...
| Autores principales: | , , , , , |
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| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
Wiley
2022
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