Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

A number of human diseases, such as arthritis and atherosclerosis, include characteristic pathology in specific anatomical locations. Here we show transcriptomic differences in synovial fibroblasts from different joint locations and that HOX gene signatures reflect the joint-specific origins of mous...

詳細記述

書誌詳細
主要な著者: Frank-Bertoncelj, M, Trenkmann, M, Klein, K, Karouzakis, E, Rehrauer, H, Bratus, A, Kolling, C, Armaka, M, Filer, A, Michel, BA, Gay, RE, Buckley, CD, Kollias, G, Gay, S, Ospelt, C
フォーマット: Journal article
出版事項: Nature Publishing Group 2017