Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

A number of human diseases, such as arthritis and atherosclerosis, include characteristic pathology in specific anatomical locations. Here we show transcriptomic differences in synovial fibroblasts from different joint locations and that HOX gene signatures reflect the joint-specific origins of mous...

Full description

Bibliographic Details
Main Authors:	Frank-Bertoncelj, M, Trenkmann, M, Klein, K, Karouzakis, E, Rehrauer, H, Bratus, A, Kolling, C, Armaka, M, Filer, A, Michel, BA, Gay, RE, Buckley, CD, Kollias, G, Gay, S, Ospelt, C
Format:	Journal article
Published:	Nature Publishing Group 2017

Similar Items

Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions
by: Mojca Frank-Bertoncelj, et al.
Published: (2017-03-01)

Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis
by: Karouzakis, E, et al.
Published: (2018)

Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis
by: Emmanuel Karouzakis, et al.
Published: (2018-05-01)

Genomic responses of mouse synovial fibroblasts during tumor necrosis factor-driven arthritogenesis greatly mimic those in human rheumatoid arthritis
by: Ntougkos, E, et al.
Published: (2017)

Endogenous Galectin-9 Suppresses Apoptosis in Human Rheumatoid Arthritis Synovial Fibroblasts
by: Pearson, MJ, et al.
Published: (2018)

The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts
by: Marietta Armaka, et al.
Published: (2018-02-01)

Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis
by: Montero-Melendez, T, et al.
Published: (2020)

TLR3 Ligand Poly(I:C) Exerts Distinct Actions in Synovial Fibroblasts When Delivered by Extracellular Vesicles
by: Mojca Frank-Bertoncelj, et al.
Published: (2018-01-01)

Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability
by: Xiangyu Ge, et al.
Published: (2021-08-01)

Differential effect of lactate on synovial fibroblast and macrophage effector functions
by: Pucino, V, et al.
Published: (2023)

Bromodomain Protein Inhibitors Reorganize the Chromatin of Synovial Fibroblasts
by: Monika Krošel, et al.
Published: (2023-04-01)

Natural killer cell and synovial fibroblast cross talk - A role in the pathogenesis of spondyloarthritis
by: Chan, A, et al.
Published: (2006)

Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage
by: Croft, AP, et al.
Published: (2016)

Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts
by: Crowley, T, et al.
Published: (2017)

Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis
by: Trinidad Montero-Melendez, et al.
Published: (2020-02-01)

Differential effect of lactate on synovial fibroblast and macrophage effector functions
by: Valentina Pucino, et al.
Published: (2023-05-01)

Association of the Rheumatoid Arthritis Severity Variant rs26232 with the Invasive Activity of Synovial Fibroblasts
by: Emma R Dorris, et al.
Published: (2019-10-01)

Hi-JAKi-ng Synovial Fibroblasts in Inflammatory Arthritis With JAK Inhibitors
by: Blaž Burja, et al.
Published: (2020-05-01)

A proinflammatory response is mediated by synovial fibroblast and natural killer cell interaction in rheumatoid arthritis and spondyloarthritis
by: Chan, A, et al.
Published: (2008)

Notch signalling drives synovial fibroblast identity and arthritis pathology
by: Wei, K, et al.
Published: (2020)

BRD3 Regulates the Inflammatory and Stress Response in Rheumatoid Arthritis Synovial Fibroblasts
by: Tanja Seifritz, et al.
Published: (2023-11-01)

Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis.
by: Vassilis Aidinis, et al.
Published: (2005-10-01)

Fibroblasts as immune regulators in infection, inflammation and cancer
by: Davidson, S, et al.
Published: (2021)

Allele-specific protein binding within the CD40 locus in human synovial fibroblasts and immune cells
by: Caroline Ospelt, et al.
Published: (2023-10-01)

ATP induced brain-derived neurotrophic factor expression and release from osteoarthritis synovial fibroblasts is mediated by purinergic receptor P2X4.
by: Kerstin Klein, et al.
Published: (2012-01-01)

Correction: Cytoskeletal Rearrangements in Synovial Fibroblasts as a Novel Pathophysiological Determinant of Modeled Rheumatoid Arthritis.
by: Vassilis Aidinis, et al.
Published: (2005-11-01)

Cyld restrains the hyperactivation of synovial fibroblasts in inflammatory arthritis by regulating the TAK1/IKK2 signaling axis
by: Vagelis Rinotas, et al.
Published: (2024-08-01)

Location, location, location: how the tissue microenvironment affects inflammation in RA
by: Buckley, CD, et al.
Published: (2021)

Single-cell multimodal analysis identifies common regulatory programs in synovial fibroblasts of rheumatoid arthritis patients and modeled TNF-driven arthritis
by: Marietta Armaka, et al.
Published: (2022-07-01)

Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells
by: Fangqi Li, et al.
Published: (2019-08-01)

Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a proinflammatory phenotype in Rheumatoid Arthritis
by: Wang, Y, et al.
Published: (2021)

Repurposing the antipsychotic drug amisulpride for targeting synovial fibroblast activation in arthritis
by: Dimitra Papadopoulou, et al.
Published: (2023-05-01)

Fibroblasts as therapeutic targets in rheumatoid arthritis and cancer
by: Maria Juarez, et al.
Published: (2012-02-01)

Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts.
by: Marlene Corbet, et al.
Published: (2021-11-01)

Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts
by: Marlene Corbet, et al.
Published: (2021-11-01)

The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels
by: Monika Krošel, et al.
Published: (2023-10-01)

Why should rheumatologists care about fibroblasts?
by: Buckley, CD
Published: (2016)

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts
by: Friščić, J, et al.
Published: (2021)

Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions
by: Noritaka Saeki, et al.
Published: (2020-11-01)

Multiomics landscape of synovial fibroblasts in rheumatoid arthritis
by: Haruka Tsuchiya, et al.
Published: (2021-03-01)