Conformational dynamics underlies different functions of human KDM7 histone demethylases

Conformational dynamics underlies different functions of human KDM7 histone demethylases

The human KDM7 subfamily histone H3 Nϵ‐methyl lysine demethylases PHF8 (KDM7B) and KIAA1718 (KDM7A) have different substrate selectivities and are linked to genetic diseases and cancer. We describe experimentally based computational studies revealing that flexibility of the region linking the PHD fi...

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Bibliographic Details
Main Authors:	Chaturvedi, S, Ramanan, R, Waheed, S, Ainsley, J, Evison, M, Ames, J, Schofield, C, Karabencheva-Christova, T, Christov, C
Format:	Journal article
Language:	English
Published:	Wiley 2019

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