Conformational dynamics underlies different functions of human KDM7 histone demethylases
The human KDM7 subfamily histone H3 Nϵ‐methyl lysine demethylases PHF8 (KDM7B) and KIAA1718 (KDM7A) have different substrate selectivities and are linked to genetic diseases and cancer. We describe experimentally based computational studies revealing that flexibility of the region linking the PHD fi...
| Main Authors: | , , , , , , , , |
|---|---|
| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
Wiley
2019
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