Conformational dynamics underlies different functions of human KDM7 histone demethylases

The human KDM7 subfamily histone H3 Nϵ‐methyl lysine demethylases PHF8 (KDM7B) and KIAA1718 (KDM7A) have different substrate selectivities and are linked to genetic diseases and cancer. We describe experimentally based computational studies revealing that flexibility of the region linking the PHD fi...

詳細記述

書誌詳細
主要な著者: Chaturvedi, S, Ramanan, R, Waheed, S, Ainsley, J, Evison, M, Ames, J, Schofield, C, Karabencheva-Christova, T, Christov, C
フォーマット: Journal article
言語:English
出版事項: Wiley 2019