The distribution of interleukin-2 receptor bearing lymphocytes in multiple sclerosis: evidence for a key role of activated lymphocytes.
The identification of T cells in the brain using monoclonal antibodies has suggested a role for T cells in the pathogenesis of multiple sclerosis (MS). In the present study the monoclonal antibody anti-Tac, shown to react with interleukin-2 (IL-2) receptors expressed on activated T cells, was used t...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1985
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| _version_ | 1797103313883234304 |
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| author | Bellamy, A Calder, V Feldmann, M Davison, A |
| author_facet | Bellamy, A Calder, V Feldmann, M Davison, A |
| author_sort | Bellamy, A |
| collection | OXFORD |
| description | The identification of T cells in the brain using monoclonal antibodies has suggested a role for T cells in the pathogenesis of multiple sclerosis (MS). In the present study the monoclonal antibody anti-Tac, shown to react with interleukin-2 (IL-2) receptors expressed on activated T cells, was used to determine levels of recently activated T cells in blood, cerebrospinal fluid (CSF) and brain sections from MS patients at different stages of disease. The CSF of MS patients contained much higher numbers of IL-2 receptor positive lymphocytes (up to 67%) than blood cells from the same patients, or the CSF of patients with non-inflammatory neurological diseases. In histological sections of the brain of MS patients with active disease, perivascular lymphocytes expressing IL-2 receptors were detected, as were lymphocytes containing IL-2. In contrast, these were absent in brain sections from patients with chronic MS, secondary demyelination or from normal controls. These observations in CSF and brain suggest that in multiple sclerosis, T-cell activation is occurring within the CNS and not in peripheral lymphoid tissue. |
| first_indexed | 2024-03-07T06:18:21Z |
| format | Journal article |
| id | oxford-uuid:f1dc0b94-74cd-4613-adf5-5be82159b2bf |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:18:21Z |
| publishDate | 1985 |
| record_format | dspace |
| spelling | oxford-uuid:f1dc0b94-74cd-4613-adf5-5be82159b2bf2022-03-27T11:59:11ZThe distribution of interleukin-2 receptor bearing lymphocytes in multiple sclerosis: evidence for a key role of activated lymphocytes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f1dc0b94-74cd-4613-adf5-5be82159b2bfEnglishSymplectic Elements at Oxford1985Bellamy, ACalder, VFeldmann, MDavison, AThe identification of T cells in the brain using monoclonal antibodies has suggested a role for T cells in the pathogenesis of multiple sclerosis (MS). In the present study the monoclonal antibody anti-Tac, shown to react with interleukin-2 (IL-2) receptors expressed on activated T cells, was used to determine levels of recently activated T cells in blood, cerebrospinal fluid (CSF) and brain sections from MS patients at different stages of disease. The CSF of MS patients contained much higher numbers of IL-2 receptor positive lymphocytes (up to 67%) than blood cells from the same patients, or the CSF of patients with non-inflammatory neurological diseases. In histological sections of the brain of MS patients with active disease, perivascular lymphocytes expressing IL-2 receptors were detected, as were lymphocytes containing IL-2. In contrast, these were absent in brain sections from patients with chronic MS, secondary demyelination or from normal controls. These observations in CSF and brain suggest that in multiple sclerosis, T-cell activation is occurring within the CNS and not in peripheral lymphoid tissue. |
| spellingShingle | Bellamy, A Calder, V Feldmann, M Davison, A The distribution of interleukin-2 receptor bearing lymphocytes in multiple sclerosis: evidence for a key role of activated lymphocytes. |
| title | The distribution of interleukin-2 receptor bearing lymphocytes in multiple sclerosis: evidence for a key role of activated lymphocytes. |
| title_full | The distribution of interleukin-2 receptor bearing lymphocytes in multiple sclerosis: evidence for a key role of activated lymphocytes. |
| title_fullStr | The distribution of interleukin-2 receptor bearing lymphocytes in multiple sclerosis: evidence for a key role of activated lymphocytes. |
| title_full_unstemmed | The distribution of interleukin-2 receptor bearing lymphocytes in multiple sclerosis: evidence for a key role of activated lymphocytes. |
| title_short | The distribution of interleukin-2 receptor bearing lymphocytes in multiple sclerosis: evidence for a key role of activated lymphocytes. |
| title_sort | distribution of interleukin 2 receptor bearing lymphocytes in multiple sclerosis evidence for a key role of activated lymphocytes |
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