Palladium catalysed elaboration of codeine and morphine
Palladium catalysed coupling reactions of 6-O-tert-butyldimethylsilyl-1-bromocodeine and 6-O-tert-butyldimethylsilyl-3-trifluoromethylsulfonylmorphine allow a range of substituted analogues of codeine in the 1-position and morphine in the 3-position to be efficiently and selectively prepared.
Main Authors: | Davies, S, Goodwin, C, Pyatt, D, Smith, A |
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格式: | Journal article |
语言: | English |
出版: |
2001
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