Hepatic resection following selective internal radiotherapy in the FOXFIRE clinical trial: survival, safety, and histopathology

Colorectal cancer (CRC) commonly metastasises to the liver and is a leading cause of cancer-related death. The FOXFIRE trial compared the safety and efficacy of radiosensitising chemotherapy (OxMdG: oxaliplatin, 5-fluorouracil and folic acid) with selective internal radiotherapy (SIRT) using yttrium...

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Bibliographic Details
Main Authors: Virdee, PS, Winter, H, Rassam, J, Goldin, R, Wasan, HS, Sharma, RA
Format: Conference item
Published: National Cancer Research Institute 2018
Description
Summary:Colorectal cancer (CRC) commonly metastasises to the liver and is a leading cause of cancer-related death. The FOXFIRE trial compared the safety and efficacy of radiosensitising chemotherapy (OxMdG: oxaliplatin, 5-fluorouracil and folic acid) with selective internal radiotherapy (SIRT) using yttrium-90 resin microspheres (SIR-Spheres®; Sirtex Medical Limited) to OxMdG alone as first-line management for liver-dominant metastatic CRC. In patients downsized to potentially-curative hepatic resection, we explored survival, safety, and histopathological findings.