A cascade strategy enables a total synthesis of (±)-morphine

Morphine has been a target for synthetic chemists since Robinson proposed its correct structure in 1925, resulting in a large number of total syntheses of morphine alkaloids. Here we report a total synthesis of (±)-morphine that employs two key strategic cyclizations: (i) a diastereoselective...

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Bibliografske podrobnosti
Main Authors: Smith, M, Chu, S, Balan, T, Münster, N
Format: Journal article
Izdano: Wiley 2016