Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells.

Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells.

The pressing need for broad-spectrum antivirals could be met by targeting host rather than viral processes. Cholesterol biosynthesis within the infected cell is one promising target for a large number of viral systems, including hepatitis C virus (HCV), hepatitis B virus (HBV) and HIV. Liposomes dev...

Podrobná bibliografie
Hlavní autoři:	Pollock, S, Nichita, N, Böhmer, A, Radulescu, C, Dwek, R, Zitzmann, N
Médium:	Journal article
Jazyk:	English
Vydáno:	National Academy of Sciences 2010

Podobné jednotky

Cholesterol level lowering liposomes
Autor: Pollock, S, a další
Vydáno: (2012)

Liposome treatment of viral infections
Autor: Dwek, R, a další
Vydáno: (2011)

Study of the mechanism of antiviral action of iminosugar derivatives against bovine viral diarrhea virus.
Autor: Durantel, D, a další
Vydáno: (2001)

Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus.
Autor: Steinmann, E, a další
Vydáno: (2007)

Endoplasmic reticulum targeting liposomes
Autor: Pollock, S, a další
Vydáno: (2011)

Glycobiology against viruses: Antiviral drug discovery
Autor: Zitzmann, N, a další
Vydáno: (2006)

Cholesterol depletion of hepatoma cells impairs hepatitis B virus envelopment by altering the topology of the large envelope protein
Autor: Dorobantu, C, a další
Vydáno: (2011)

N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery.
Autor: Pollock, S, a další
Vydáno: (2008)

Uptake and trafficking of liposomes to the endoplasmic reticulum
Autor: Pollock, S, a další
Vydáno: (2010)

Antiviral effect of N-butyldeoxynojirimycin against bovine viral diarrhea virus correlates with misfolding of E2 envelope proteins and impairment of their association into E1-E2 heterodimers.
Autor: Branza-Nichita, N, a další
Vydáno: (2001)

The bovine viral diarrhoea virus: a model for the study of antiviral molecules interfering with N-glycosylation and folding of envelope glycoprotein
Autor: Durantel, D, a další
Vydáno: (2015)

Hepatitis B virus requires intact caveolin-1 function for productive infection in HepaRG cells.
Autor: Macovei, A, a další
Vydáno: (2010)

Liposome-mediated delivery of iminosugars enhances efficacy against dengue virus in vivo.
Autor: Miller, J, a další
Vydáno: (2012)

Targeting the host ER alpha glucosidases I and II as antiviral therapy
Autor: Branza-Nichita, N, a další
Vydáno: (2007)

Mechanisms of antiviral activity of iminosugars against dengue virus
Autor: Miller, JL, a další
Vydáno: (2018)

Targeting a host process as an antiviral approach against dengue virus
Autor: Sayce, A, a další
Vydáno: (2010)

Treatment of hepatitis B virus-infected cells with alpha-glucosidase inhibitors results in production of virions with altered molecular composition and infectivity.
Autor: Lazar, C, a další
Vydáno: (2007)

Virus morphogenesis and viral entry as alternative targets for novel hepatitis C antivirals
Autor: Chapel, C, a další
Vydáno: (2006)

Antiviral effect of alpha-glucosidase inhibitors on viral morphogenesis and binding properties of hepatitis C virus-like particles.
Autor: Chapel, C, a další
Vydáno: (2006)

Iminosugar antivirals: the therapeutic sweet spot
Autor: Alonzi, D, a další
Vydáno: (2017)

Effects of interferon, ribavirin, and iminosugar derivatives on cells persistently infected with noncytopathic bovine viral diarrhea virus.
Autor: Durantel, D, a další
Vydáno: (2004)

Host-targeting oral antiviral drugs to prevent pandemics
Autor: Dwek, RA, a další
Vydáno: (2022)

Use of castanospermine and substituted-castonospermine compounds for treating hepatitis virus infections
Autor: Jacob, G, a další
Vydáno: (2001)

Protein-protein interactions: modeling the hepatitis C virus ion channel p7.
Autor: Patargias, G, a další
Vydáno: (2005)

The Hepatitis C Virus E2p7 localization and topology in a recombinant system
Autor: Popescu, C, a další
Vydáno: (2009)

Glycyrrhizin as antiviral agent against Hepatitis C Virus
Autor: Ashfaq Usman A, a další
Vydáno: (2011-07-01)

Antiviral effects of an iminosugar derivative on flavivirus infections.
Autor: Wu, S, a další
Vydáno: (2002)

Strain-specific antiviral activity of iminosugars against human influenza A viruses.
Autor: Hussain, S, a další
Vydáno: (2015)

Role of N-glycan trimming in the folding and secretion of the pestivirus protein E(rns)
Autor: Branza-Nichita, N, a další
Vydáno: (2004)

The pestivirus E(rns) glycoprotein interacts with E2 in both infected cells and mature virions.
Autor: Lazar, C, a další
Vydáno: (2003)

Discovery of antiviral small molecules against Hepatitis C virus
Autor: Li, Enlin
Vydáno: (2014)

Potential antiviral activities of chrysin against hepatitis B virus
Autor: Sajad Ahmad Bhat, a další
Vydáno: (2023-03-01)

Drug Delivery Strategies for Antivirals against Hepatitis B Virus
Autor: Latavia Singh, a další
Vydáno: (2018-05-01)

Iminosugars in combination with interferon and ribavirin permanently eradicate noncytopathic bovine viral diarrhea virus from persistently infected cells.
Autor: Woodhouse, S, a další
Vydáno: (2008)

Bypass of quality control in protein folding pathways induces specific misfolding of HIV envelope V2 loop: implications for iminosugars as antivirals
Autor: Spiro, S, a další
Vydáno: (2014)

Conservation of hydrophobicity within viral envelope glycoproteins reveals a putative hepatitis C virus fusion peptide
Autor: Taylor, A, a další
Vydáno: (2009)

Clinical diagnosis of hepatic fibrosis using human serum APOL1 as biomarker
Autor: Gangadharan, B, a další
Vydáno: (2012)

The Effect of Antiviral Therapy on Serum Cholesterol Levels in Chronic Hepatitis C
Vydáno: (2011-09-01)

Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: Implications for the development of broad spectrum anti-hepatitis virus agents
Autor: Zitzmann, N, a další
Vydáno: (1999)

Clinical diagnosis of hepatic fibrosis using a novel panel of human serum protein biomarkers
Autor: Gangadharan, B, a další
Vydáno: (2008)