The method of silent substitution for examining melanopsin contributions to pupil control
The human pupillary light response is driven by all classes of photoreceptors in the human eye—the three classes of cones, the rods, and the intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin. These photoreceptor classes have distinct but overlapping...
| Κύριοι συγγραφείς: | , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
Frontiers Media
2018
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| _version_ | 1826304534813605888 |
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| author | Spitschan, M Woelders, T |
| author_facet | Spitschan, M Woelders, T |
| author_sort | Spitschan, M |
| collection | OXFORD |
| description | The human pupillary light response is driven by all classes of photoreceptors in the human eye—the three classes of cones, the rods, and the intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin. These photoreceptor classes have distinct but overlapping spectral tuning, and even a monochromatic light with a wavelength matched to the peak spectral sensitivity of a given photoreceptor will stimulate all photoreceptors. The method of silent substitution uses pairs of lights (“metamers”) to selectively stimulate a given class of photoreceptors while keeping the activation of all others constant. In this primer, we describe the method of silent substitution and provide an overview of studies that have used it to examine inputs to the human pupillary light response. |
| first_indexed | 2024-03-07T06:19:17Z |
| format | Journal article |
| id | oxford-uuid:f22e6a2a-0e0c-49f3-8846-a4ebd0a30c66 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:19:17Z |
| publishDate | 2018 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:f22e6a2a-0e0c-49f3-8846-a4ebd0a30c662022-03-27T12:01:33ZThe method of silent substitution for examining melanopsin contributions to pupil controlJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f22e6a2a-0e0c-49f3-8846-a4ebd0a30c66EnglishSymplectic Elements at OxfordFrontiers Media2018Spitschan, MWoelders, TThe human pupillary light response is driven by all classes of photoreceptors in the human eye—the three classes of cones, the rods, and the intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin. These photoreceptor classes have distinct but overlapping spectral tuning, and even a monochromatic light with a wavelength matched to the peak spectral sensitivity of a given photoreceptor will stimulate all photoreceptors. The method of silent substitution uses pairs of lights (“metamers”) to selectively stimulate a given class of photoreceptors while keeping the activation of all others constant. In this primer, we describe the method of silent substitution and provide an overview of studies that have used it to examine inputs to the human pupillary light response. |
| spellingShingle | Spitschan, M Woelders, T The method of silent substitution for examining melanopsin contributions to pupil control |
| title | The method of silent substitution for examining melanopsin contributions to pupil control |
| title_full | The method of silent substitution for examining melanopsin contributions to pupil control |
| title_fullStr | The method of silent substitution for examining melanopsin contributions to pupil control |
| title_full_unstemmed | The method of silent substitution for examining melanopsin contributions to pupil control |
| title_short | The method of silent substitution for examining melanopsin contributions to pupil control |
| title_sort | method of silent substitution for examining melanopsin contributions to pupil control |
| work_keys_str_mv | AT spitschanm themethodofsilentsubstitutionforexaminingmelanopsincontributionstopupilcontrol AT woelderst themethodofsilentsubstitutionforexaminingmelanopsincontributionstopupilcontrol AT spitschanm methodofsilentsubstitutionforexaminingmelanopsincontributionstopupilcontrol AT woelderst methodofsilentsubstitutionforexaminingmelanopsincontributionstopupilcontrol |