Elastic correlations in nucleosomal DNA structure.
The structure of DNA in the nucleosome core particle is studied using an elastic model that incorporates anisotropy in the bending energetics and twist-bend coupling. Using the experimentally determined structure of nucleosomal DNA [T. J. Richmond and C. A. Davey, Nature (London) 423, 145 (2003)], i...
| Main Authors: | , |
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| 格式: | Journal article |
| 语言: | English |
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2005
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| _version_ | 1826304536987303936 |
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| author | Mohammad-Rafiee, F Golestanian, R |
| author_facet | Mohammad-Rafiee, F Golestanian, R |
| author_sort | Mohammad-Rafiee, F |
| collection | OXFORD |
| description | The structure of DNA in the nucleosome core particle is studied using an elastic model that incorporates anisotropy in the bending energetics and twist-bend coupling. Using the experimentally determined structure of nucleosomal DNA [T. J. Richmond and C. A. Davey, Nature (London) 423, 145 (2003)], it is shown that elastic correlations exist between twist, roll, tilt, and stretching of DNA, as well as the distance between phosphate groups. The twist-bend coupling term is shown to be able to capture these correlations to a large extent, and a fit to the experimental data yields a new estimate of G = 25 nm for the value of the twist-bend coupling constant. |
| first_indexed | 2024-03-07T06:19:19Z |
| format | Journal article |
| id | oxford-uuid:f232cf1a-ddbf-492d-8a0d-e9c879de0792 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:19:19Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:f232cf1a-ddbf-492d-8a0d-e9c879de07922022-03-27T12:01:40ZElastic correlations in nucleosomal DNA structure.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f232cf1a-ddbf-492d-8a0d-e9c879de0792EnglishSymplectic Elements at Oxford2005Mohammad-Rafiee, FGolestanian, RThe structure of DNA in the nucleosome core particle is studied using an elastic model that incorporates anisotropy in the bending energetics and twist-bend coupling. Using the experimentally determined structure of nucleosomal DNA [T. J. Richmond and C. A. Davey, Nature (London) 423, 145 (2003)], it is shown that elastic correlations exist between twist, roll, tilt, and stretching of DNA, as well as the distance between phosphate groups. The twist-bend coupling term is shown to be able to capture these correlations to a large extent, and a fit to the experimental data yields a new estimate of G = 25 nm for the value of the twist-bend coupling constant. |
| spellingShingle | Mohammad-Rafiee, F Golestanian, R Elastic correlations in nucleosomal DNA structure. |
| title | Elastic correlations in nucleosomal DNA structure. |
| title_full | Elastic correlations in nucleosomal DNA structure. |
| title_fullStr | Elastic correlations in nucleosomal DNA structure. |
| title_full_unstemmed | Elastic correlations in nucleosomal DNA structure. |
| title_short | Elastic correlations in nucleosomal DNA structure. |
| title_sort | elastic correlations in nucleosomal dna structure |
| work_keys_str_mv | AT mohammadrafieef elasticcorrelationsinnucleosomaldnastructure AT golestanianr elasticcorrelationsinnucleosomaldnastructure |