Cotranslational protein folding--fact or fiction?
MOTIVATION: Experimentalists have amassed extensive evidence over the past four decades that proteins appear to fold during production by the ribosome. Protein structure prediction methods, however, do not incorporate this property of folding. A thorough study to find the fingerprint of such sequen...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1826304556638666752 |
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| author | Deane, C Dong, M Huard, F Lance, B Wood, G |
| author_facet | Deane, C Dong, M Huard, F Lance, B Wood, G |
| author_sort | Deane, C |
| collection | OXFORD |
| description | MOTIVATION: Experimentalists have amassed extensive evidence over the past four decades that proteins appear to fold during production by the ribosome. Protein structure prediction methods, however, do not incorporate this property of folding. A thorough study to find the fingerprint of such sequential folding is the first step towards using it in folding algorithms, so assisting structure prediction. RESULTS: We explore computationally the existence of evidence for cotranslational folding, based on large sets of experimentally determined structures in the PDB. Our perspective is that cotranslational folding is the norm, but that the effect is masked in most classes. We show that it is most evident in alpha/beta proteins, confirming recent findings. We also find mild evidence that older proteins may fold cotranslationally. A tool is provided for determining, within a protein, where cotranslation is most evident. |
| first_indexed | 2024-03-07T06:19:37Z |
| format | Journal article |
| id | oxford-uuid:f2499f5e-7ddc-45e9-abc7-03f3cb5b1b99 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:19:37Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:f2499f5e-7ddc-45e9-abc7-03f3cb5b1b992022-03-27T12:02:28ZCotranslational protein folding--fact or fiction?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f2499f5e-7ddc-45e9-abc7-03f3cb5b1b99EnglishSymplectic Elements at Oxford2007Deane, CDong, MHuard, FLance, BWood, G MOTIVATION: Experimentalists have amassed extensive evidence over the past four decades that proteins appear to fold during production by the ribosome. Protein structure prediction methods, however, do not incorporate this property of folding. A thorough study to find the fingerprint of such sequential folding is the first step towards using it in folding algorithms, so assisting structure prediction. RESULTS: We explore computationally the existence of evidence for cotranslational folding, based on large sets of experimentally determined structures in the PDB. Our perspective is that cotranslational folding is the norm, but that the effect is masked in most classes. We show that it is most evident in alpha/beta proteins, confirming recent findings. We also find mild evidence that older proteins may fold cotranslationally. A tool is provided for determining, within a protein, where cotranslation is most evident. |
| spellingShingle | Deane, C Dong, M Huard, F Lance, B Wood, G Cotranslational protein folding--fact or fiction? |
| title | Cotranslational protein folding--fact or fiction? |
| title_full | Cotranslational protein folding--fact or fiction? |
| title_fullStr | Cotranslational protein folding--fact or fiction? |
| title_full_unstemmed | Cotranslational protein folding--fact or fiction? |
| title_short | Cotranslational protein folding--fact or fiction? |
| title_sort | cotranslational protein folding fact or fiction |
| work_keys_str_mv | AT deanec cotranslationalproteinfoldingfactorfiction AT dongm cotranslationalproteinfoldingfactorfiction AT huardf cotranslationalproteinfoldingfactorfiction AT lanceb cotranslationalproteinfoldingfactorfiction AT woodg cotranslationalproteinfoldingfactorfiction |