Serotonin receptor subtypes: implications for psychopharmacology.
Serotonin (5-HT) interacts with multiple brain 5-HT receptor subtypes to influence a wide range of behaviours. Three main families of 5-HT receptors (5-HT1, 5-HT2 and 5-HT3) have been described which differ in their binding affinity for selective ligands, their receptor-effector coupling mechanisms,...
| מחבר ראשי: | |
|---|---|
| פורמט: | Journal article |
| שפה: | English |
| יצא לאור: |
1991
|
| _version_ | 1826304561332092928 |
|---|---|
| author | Cowen, P |
| author_facet | Cowen, P |
| author_sort | Cowen, P |
| collection | OXFORD |
| description | Serotonin (5-HT) interacts with multiple brain 5-HT receptor subtypes to influence a wide range of behaviours. Three main families of 5-HT receptors (5-HT1, 5-HT2 and 5-HT3) have been described which differ in their binding affinity for selective ligands, their receptor-effector coupling mechanisms, and the behavioural processes they regulate. Nevertheless, manipulation of several different 5-HT receptor subtypes (5-HT1A, 5-HT1C, 5-HT2 and 5-HT3) may produce anxiolytic effects; 5-HT1A and 5-HT2 receptors may be involved in the aetiology of major depression and the therapeutic effects of antidepressant treatment; and 5-HT3 receptors have been linked to reward mechanisms and cognitive processes. These advances offer therapeutic possibilities, the value of which can only be satisfactorily assessed by controlled clinical trials. |
| first_indexed | 2024-03-07T06:19:42Z |
| format | Journal article |
| id | oxford-uuid:f24db004-58d0-4de5-a226-b7f378759638 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:19:42Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:f24db004-58d0-4de5-a226-b7f3787596382022-03-27T12:02:44ZSerotonin receptor subtypes: implications for psychopharmacology.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f24db004-58d0-4de5-a226-b7f378759638EnglishSymplectic Elements at Oxford1991Cowen, PSerotonin (5-HT) interacts with multiple brain 5-HT receptor subtypes to influence a wide range of behaviours. Three main families of 5-HT receptors (5-HT1, 5-HT2 and 5-HT3) have been described which differ in their binding affinity for selective ligands, their receptor-effector coupling mechanisms, and the behavioural processes they regulate. Nevertheless, manipulation of several different 5-HT receptor subtypes (5-HT1A, 5-HT1C, 5-HT2 and 5-HT3) may produce anxiolytic effects; 5-HT1A and 5-HT2 receptors may be involved in the aetiology of major depression and the therapeutic effects of antidepressant treatment; and 5-HT3 receptors have been linked to reward mechanisms and cognitive processes. These advances offer therapeutic possibilities, the value of which can only be satisfactorily assessed by controlled clinical trials. |
| spellingShingle | Cowen, P Serotonin receptor subtypes: implications for psychopharmacology. |
| title | Serotonin receptor subtypes: implications for psychopharmacology. |
| title_full | Serotonin receptor subtypes: implications for psychopharmacology. |
| title_fullStr | Serotonin receptor subtypes: implications for psychopharmacology. |
| title_full_unstemmed | Serotonin receptor subtypes: implications for psychopharmacology. |
| title_short | Serotonin receptor subtypes: implications for psychopharmacology. |
| title_sort | serotonin receptor subtypes implications for psychopharmacology |
| work_keys_str_mv | AT cowenp serotoninreceptorsubtypesimplicationsforpsychopharmacology |