Microparticles and immunomodulation in pregnancy and pre-eclampsia.
Cellular microparticles are ubiquitously shed from cell membranes or secreted as endocytic vesicles called exosomes. Shed microparticles are >/=100nm in size and are generated during apoptosis or necrosis. In contrast, exosomes are smaller (<100nm), express more limited protein content...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1797103407212789760 |
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| author | Redman, C Sargent, I |
| author_facet | Redman, C Sargent, I |
| author_sort | Redman, C |
| collection | OXFORD |
| description | Cellular microparticles are ubiquitously shed from cell membranes or secreted as endocytic vesicles called exosomes. Shed microparticles are >/=100nm in size and are generated during apoptosis or necrosis. In contrast, exosomes are smaller (<100nm), express more limited protein content and are released from late endosomes. Both membrane particles and exosomes can be detected in the circulation in non-pregnant and pregnant women. In the former, they are increased in conditions associated with systemic inflammation such as sepsis or metabolic syndrome. During pregnancy, they are also associated with pre-eclampsia and include not only particles derived from platelets, endothelium and various leukocytes but also syncytiotrophoblast-derived microparticles. Syncytiotrophoblast membrane microparticles (often called STBMs) interact with both immune and endothelial cells. They may contribute to the systemic inflammatory response of both normal and pre-eclamptic pregnancies, although inhibitory activity has also been described. Moreover, trophoblast-derived exosomes may contribute to or cause the downregulation of T cell activity that has been repeatedly observed during pregnancy. Deletion of activate T cells which express Fas ligand by Fas-expressing exosomes derived from trophoblast may contribute to immunoregulation necessary for normal pregnancy. |
| first_indexed | 2024-03-07T06:19:44Z |
| format | Journal article |
| id | oxford-uuid:f252d36b-c340-4157-bb99-84a78da7d702 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:19:44Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:f252d36b-c340-4157-bb99-84a78da7d7022022-03-27T12:02:47ZMicroparticles and immunomodulation in pregnancy and pre-eclampsia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f252d36b-c340-4157-bb99-84a78da7d702EnglishSymplectic Elements at Oxford2007Redman, CSargent, ICellular microparticles are ubiquitously shed from cell membranes or secreted as endocytic vesicles called exosomes. Shed microparticles are >/=100nm in size and are generated during apoptosis or necrosis. In contrast, exosomes are smaller (<100nm), express more limited protein content and are released from late endosomes. Both membrane particles and exosomes can be detected in the circulation in non-pregnant and pregnant women. In the former, they are increased in conditions associated with systemic inflammation such as sepsis or metabolic syndrome. During pregnancy, they are also associated with pre-eclampsia and include not only particles derived from platelets, endothelium and various leukocytes but also syncytiotrophoblast-derived microparticles. Syncytiotrophoblast membrane microparticles (often called STBMs) interact with both immune and endothelial cells. They may contribute to the systemic inflammatory response of both normal and pre-eclamptic pregnancies, although inhibitory activity has also been described. Moreover, trophoblast-derived exosomes may contribute to or cause the downregulation of T cell activity that has been repeatedly observed during pregnancy. Deletion of activate T cells which express Fas ligand by Fas-expressing exosomes derived from trophoblast may contribute to immunoregulation necessary for normal pregnancy. |
| spellingShingle | Redman, C Sargent, I Microparticles and immunomodulation in pregnancy and pre-eclampsia. |
| title | Microparticles and immunomodulation in pregnancy and pre-eclampsia. |
| title_full | Microparticles and immunomodulation in pregnancy and pre-eclampsia. |
| title_fullStr | Microparticles and immunomodulation in pregnancy and pre-eclampsia. |
| title_full_unstemmed | Microparticles and immunomodulation in pregnancy and pre-eclampsia. |
| title_short | Microparticles and immunomodulation in pregnancy and pre-eclampsia. |
| title_sort | microparticles and immunomodulation in pregnancy and pre eclampsia |
| work_keys_str_mv | AT redmanc microparticlesandimmunomodulationinpregnancyandpreeclampsia AT sargenti microparticlesandimmunomodulationinpregnancyandpreeclampsia |