Cyclin-dependent kinases: masters of the eukaryotic universe

A family of structurally related cyclin-dependent protein kinases (CDKs) drives many aspects of eukaryotic cell function. Much of the literature in this area has considered individual members of this family to act primarily either as regulators of the cell cycle, the context in which CDKs were first...

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Main Authors: Pluta, AJ, Studniarek, C, Murphy, S, Norbury, CJ
Format: Journal article
Language:English
Published: Wiley 2023
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author Pluta, AJ
Studniarek, C
Murphy, S
Norbury, CJ
author_facet Pluta, AJ
Studniarek, C
Murphy, S
Norbury, CJ
author_sort Pluta, AJ
collection OXFORD
description A family of structurally related cyclin-dependent protein kinases (CDKs) drives many aspects of eukaryotic cell function. Much of the literature in this area has considered individual members of this family to act primarily either as regulators of the cell cycle, the context in which CDKs were first discovered, or as regulators of transcription. Until recently, CDK7 was the only clear example of a CDK that functions in both processes. However, new data points to several “cell-cycle” CDKs having important roles in transcription and some “transcriptional” CDKs having cell cycle-related targets. For example, novel functions in transcription have been demonstrated for the archetypal cell cycle regulator CDK1. The increasing evidence of the overlap between these two CDK types suggests that they might play a critical role in coordinating the two processes. Here we review the canonical functions of cell-cycle and transcriptional CDKs, and provide an update on how these kinases collaborate to perform important cellular functions. We also provide a brief overview of how dysregulation of CDKs contributes to carcinogenesis, and possible treatment avenues.
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spelling oxford-uuid:f25e1714-50bf-4ea5-bd9c-dbbea6ac99762024-02-09T11:26:55ZCyclin-dependent kinases: masters of the eukaryotic universeJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f25e1714-50bf-4ea5-bd9c-dbbea6ac9976EnglishSymplectic ElementsWiley2023Pluta, AJStudniarek, CMurphy, SNorbury, CJA family of structurally related cyclin-dependent protein kinases (CDKs) drives many aspects of eukaryotic cell function. Much of the literature in this area has considered individual members of this family to act primarily either as regulators of the cell cycle, the context in which CDKs were first discovered, or as regulators of transcription. Until recently, CDK7 was the only clear example of a CDK that functions in both processes. However, new data points to several “cell-cycle” CDKs having important roles in transcription and some “transcriptional” CDKs having cell cycle-related targets. For example, novel functions in transcription have been demonstrated for the archetypal cell cycle regulator CDK1. The increasing evidence of the overlap between these two CDK types suggests that they might play a critical role in coordinating the two processes. Here we review the canonical functions of cell-cycle and transcriptional CDKs, and provide an update on how these kinases collaborate to perform important cellular functions. We also provide a brief overview of how dysregulation of CDKs contributes to carcinogenesis, and possible treatment avenues.
spellingShingle Pluta, AJ
Studniarek, C
Murphy, S
Norbury, CJ
Cyclin-dependent kinases: masters of the eukaryotic universe
title Cyclin-dependent kinases: masters of the eukaryotic universe
title_full Cyclin-dependent kinases: masters of the eukaryotic universe
title_fullStr Cyclin-dependent kinases: masters of the eukaryotic universe
title_full_unstemmed Cyclin-dependent kinases: masters of the eukaryotic universe
title_short Cyclin-dependent kinases: masters of the eukaryotic universe
title_sort cyclin dependent kinases masters of the eukaryotic universe
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AT studniarekc cyclindependentkinasesmastersoftheeukaryoticuniverse
AT murphys cyclindependentkinasesmastersoftheeukaryoticuniverse
AT norburycj cyclindependentkinasesmastersoftheeukaryoticuniverse