A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk

<p style="text-align:justify;"> <b>Background:</b> Mitotic recombination is important for inactivating tumour suppressor genes by copy-neutral loss of heterozygosity (LOH). Although meiotic recombination maps are plentiful, little is known about mitotic recombination. Th...

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Main Authors: Howarth, K, Ranta, S, Winter, E, Teixeira, A, Schaschl, H, Harvey, J, Rowan, A, Jones, A, Spain, S, Clark, S, Guenther, T, Stewart, A, Silver, A, Tomlinson, I
Format: Journal article
Language:English
Published: BioMed Central 2009