PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.
DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coord...
Autores principales: | Mootha, V, Lindgren, C, Eriksson, K, Subramanian, A, Sihag, S, Lehar, J, Puigserver, P, Carlsson, E, Ridderstråle, M, Laurila, E, Houstis, N, Daly, M, Patterson, N, Mesirov, J, Golub, T, Tamayo, P, Spiegelman, B, Lander, E, Hirschhorn, J, Altshuler, D, Groop, L |
---|---|
Formato: | Journal article |
Lenguaje: | English |
Publicado: |
2003
|
Ejemplares similares
-
Gene expression profiling in skeletal muscle of subjects with different glycaemic tolerance.
por: Lindgren, C, et al.
Publicado: (2001) -
Large-scale, family-based, candidate gene association study of type 2 diabetes mellitus and abdominal obesity
por: Hirschhorn, J, et al.
Publicado: (2000) -
Linkage disequilibrium at PPARG and other genes assessed with dense sets of SNPs..
por: Hirschhorn, J, et al.
Publicado: (2001) -
Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height.
por: Hirschhorn, J, et al.
Publicado: (2001) -
The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes.
por: Altshuler, D, et al.
Publicado: (2000)